高原肺水肿发生机制与临床转化的现状与展望  

Mechanisms and clinical translation of high altitude pulmonary edema:current status and future prospects

作　　者：高文祥 吴刚[1,2,3] 徐立聪 高钰琪[1,2,3] Gao Wenxiang;Wu Gang;Xu Licong;Gao Yuqi(College of High Altitude Military Medicine,Institute of Medicine and Hygienic Equipment for High Altitude Region,Army Medical University,Chongqing 400038,China;Key Laboratory of Extreme Environmental Medicine,Ministry of Education of China,Chongqing 400038,China;Key Laboratory of High Altitude Medicine,PLA,Chongqing 400038,China;Institute of Hypoxia Medicine,Wenzhou Medical University,Wenzhou 325035,Zhejiang,China)

机构地区：[1]陆军军医大学高原军事医学系高原特需药品与器材研究室,重庆400038 [2]极端环境医学教育部重点实验室,重庆400038 [3]军队高原医学重点实验室,重庆400038 [4]温州医科大学低氧医学研究所,浙江温州325035

出　　处：《生物医学转化》2021年第2期1-7,71,共8页Biomedical transformation

基　　金：国家自然科学基金项目(NSFC81471814);极端环境医学教育部重点实验室开放课题(KL2019GY004)。

摘　　要：高原肺水肿(HighAltitudePulmonaryEdema,HAPE)是一种高原特发性非心源性肺水肿,病情重,病死率高。目前认为HAPE的发生机制主要为低氧性肺动脉压力过度增高、肺血管通透性增高、肺水清除障碍、液体贮留及体液转运失调。本文综述了HAPE发生机制的研究进展,以及针对其关键环节防治HAPE的临床转化现状与前景,为寻找HAPE防治新措施提供参考。High altitude pulmonary edema(HAPE) is a form of life-threatening high altitude idiopathy.This non-cardiogenic pulmonary edema is a serious illness with high risk of morbidity. The mechanisms of HAPE mostly proposed so far in literature include exaggerated hypoxic pulmonary vasoconstriction(HPV) and excessively increased capillary pressure, pulmonary capillary leak, disturbed alveolar fluid clearance, and liquid retention and body fluid imbalance. In this review, we described the advances in HAPE mechanisms and in the clinical translation of therapeutics targeting the central links of HAPE pathophysiology. We also provided views on the future prospects for the pharmacological management of HAPE, which should inspire high altitude medical researchers to find new measures to prevent and treat HAPE.

关 键 词：高原肺水肿 发生机制 临床转化 

分 类 号：R563.9[医药卫生—呼吸系统] R363.21[医药卫生—内科学]