促排卵过程中孕酮升高原因及对IVF/ICSI结局影响的研究进展  

Research progress on causes of elevated progesterone during ovulation induction and its influence on IVF/ICSI outcome

作　　者：霍建玮 刘芸 HUO Jian-wei;LIU Yun(Fuzhou General Clinical Medical College of Fujian Medical University,Center for Reproductive Medmicine,900th Hospital of the Joint Logistics Team,Fuzhou 350025)

机构地区：[1]福建医科大学福总临床医学院联勤保障部队第九○○医院生殖医学中心,福州350025

出　　处：《生殖医学杂志》2021年第6期820-826,共7页Journal of Reproductive Medicine

基　　金：军队计生专业科研课题(16JS013)。

摘　　要：在辅助生殖技术(ART)控制性促排卵(COH)过程中,晚卵泡期孕酮经常提前升高,对子宫内膜的容受性造成一定损害,导致鲜胚移植妊娠率降低,增加全胚冷冻的几率。晚卵泡期孕酮升高的原因有很多,包括肾上腺来源增多、生长卵泡数目、血清雌激素水平、促卵泡刺激素(FSH)使用剂量以及LH水平影响等。晚卵泡期孕酮升高对IVF/ICSI结局的影响也有了新进展。本文针对近年来COH过程中晚卵泡期孕酮升高的原因及其对IVF/ICSI结局影响的相关研究做一个综述。During the process of controlled ovarian hyperstimulation(COH)of assisted reproductive technology(ART),progesterone often elevates early in the late follicular period,which causes certain damage to the endometrial receptivity,resulting in a decrease in the pregnancy rate of fresh embryo transfer and an increase the probability of whole embryo freezing.There are many causes for the increase of progesterone in the late follicular period,including the increase of source of adrenal gland,the number of growing follicles,the serum level of estrogen,the dosage of FSH used and the influence of LH level.The study of impact of elevated progesterone in late follicular phase on IVF/ICSI outcomes has also made new progress.This paper reviews the causes for the increase of progesterone in the late follicular phase during COH in recent years and its impact on IVF/ICSI outcomes.

关 键 词：控制性促排卵 晚卵泡期 孕酮 胚胎移植 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]