分析尼可地尔对稳定型微血管病性心绞痛的治疗效果  

Analysis of the Therapeutic Effect of Nicorandil on Stable Microangiopathic Angina Pectoris

作　　者：张姝杰[1] ZHANG Shujie(Department of Cardiology,Central Hospital of Zibo Mining Group Co.,Ltd.,Zibo,Shandong Province,255120 China)

机构地区：[1]淄博矿业集团有限责任公司中心医院心内科,山东淄博255120

出　　处：《中外医疗》2021年第12期98-100,共3页China & Foreign Medical Treatment

摘　　要：目的探讨尼可地尔对稳定型微血管病性心绞痛治疗效果的作用。方法方便选择该院2017年7月—2018年7月130例稳定型微血管病性心绞痛患者作为研究对象,应用计算机表法分组处理,将全部患者分成两组,观察组、参照组,每组65例。观察组采用尼可地尔方案治疗,参照组施行常规方法治疗,对两组临床效果进行比较。结果①观察组的治疗总有效率92.31%,与参照组的治疗总有效率78.46%比较,差异有统计学意义(χ^(2)=4.993,P=0.025)。②观察组的不良反应发生率7.69%,与参照组的不良反应发生率20.00%对比,差异有统计学意义(χ^(2)=4.127,P=0.042)。③治疗前,观察组和参照组的心绞痛发作频率分别为(11.05±1.82)次/周、(10.97±1.78)次/周,差异无统计学意义(t=0.253,P=0.800);治疗后,观察组和参照组的心绞痛发作频率分别为(3.79±1.58)次/周、(5.43±1.62)次/周,差异有统计学意义(t=5.843,P<0.001)。结论稳定型微血管病性心绞痛患者接受尼可地尔治疗,在治疗效果及安全性方面优势突出,并且能够有效减少心绞痛的发作频率,故此建议在临床方面应用并推广。Objective To explore the effect of nicorandil on stable microangiopathic angina pectoris.Methods 130 patients with stable microangiopathic angina pectoris in the hospital from July 2017 to July 2018 were conveniently selected as the study objects.The patients were grouped and processed by computer table method.All the patients were divided into two groups,namely the observation group and the reference group.There were 65 cases in each group.The observation group was treated with nicorandil regimen,the reference group was treated with conventional methods,and the clinical effects of the two groups were compared.Results 1.The total effective rate of treatment in the observation group was 92.31%,compared with the total effective rate of 78.46%in the reference group,the difference was statistically significant(χ^(2)=4.993,P=0.025).2.The incidence of adverse reactions in the observation group was 7.69%.Compared with the incidence of 20.00%in the reference group,the difference was statistically significant(χ^(2)=4.127,P=0.042).3.Before treatment,the frequency of angina pectoris in the observation group and the reference group was(11.05±1.82)times/week,(10.97±1.78)times/week,the difference was not statistically significant(t=0.253,P=0.800);after treatment,the frequency of angina pectoris in the observation group and the reference group was(3.79±1.58)times/week and(5.43±1.62)times/week,the difference was statistically significant(t=5.843,P<0.001).Conclusion Nicorandil treatment for patients with stable microangiopathic angina pectoris has outstanding advantages in therapeutic effect and safety,and can effectively reduce the frequency of angina pectoris.Therefore,it is recommended to be applied and promoted in clinical applications.

关 键 词：尼可地尔 稳定型微血管病性心绞痛 治疗效果 

分 类 号：R541.4[医药卫生—心血管疾病]