基于M2e的广谱流感疫苗及其免疫保护机制研究进展  

The Progress and Perspectives of M2e-Based Universal Influenza A Vaccines and Immune Protection Mechanism

作　　者：尹元 王正印 邢嘉翌 赵俊梅 赵延荣 陆群 YIN Yuan;WANG Zhengyin;XING Jiayi;ZHAO Junmei;ZHAO Yanrong;LU Qun(Department of Clinical Laboratory, Shanghai Traditional Chinese Medicine- Integrated Hospital,Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China)

机构地区：[1]上海中医药大学附属上海市中西医结合医院检验科,上海200082

出　　处：《标记免疫分析与临床》2021年第4期697-702,共6页Labeled Immunoassays and Clinical Medicine

基　　金：上海市卫生健康委员会科研课题青年项目(编号:20174Y0016);上海市卫生健康委员会卫生行业临床研究专项(编号:201840016)。

摘　　要：疫苗接种是预防流感最有效和经济的手段。当前使用的流感疫苗主要是作用于特异性的流感病毒表面糖蛋白血凝素,只能对和疫苗株匹配的流行株提供保护,因此每年需要对疫苗株进行更新。研发能够预防不同亚型流感病毒的广谱疫苗成为流感疫苗研究的热点。M2e是甲型流感病毒保守片段,可作为广谱流感疫苗的候选抗原,是目前广谱流感疫苗研究的热点。本文将就M2e广谱流感疫苗及其免疫保护机制的研究进展作一综述。Nowadays,vaccination is still the most effective and cost-effective strategy to prevent the influenza pandemic outbreaks.Current influenza virus vaccines are based on strain-specific surface glycoprotein hemagglutinin(HA)antigens and effective only when the predicted vaccine strains and circulating viruses are well-matched.Because of this mechanism,the composition of influenza vaccines needs to be updated every year.The extracellular domain of the M2 protein(M2e)of influenza A virus is a conservative region,and can serve as an attractive target for a universal influenza vaccine.In this paper,we summarize the latest developments in the preparation and the mechanism of M2e-based universal influenza vaccines.

关 键 词：甲型流感病毒 M2蛋白胞外区 广谱流感疫苗 免疫机制 

分 类 号：R373.1+3[医药卫生—病原生物学]