养肺益肾颗粒治疗肺肾气阴两虚证慢性阻塞性肺疾病稳定期临床研究  

Clinical Study on Yangfei Yishen Granules for Chronic Obstructive Pulmonary Disease with Syndrome of Qi-Yin Deficiency in Lung and Kidney at Stable Stage

作　　者：李强[1] 翟春苗 周佳[1] 巨君芳[1] LI Qiang;ZHAI Chunmiao;ZHOU Jia;JU Junfang

机构地区：[1]杭州市中医院老年病科,浙江杭州310007

出　　处：《新中医》2021年第9期31-35,共5页New Chinese Medicine

基　　金：杭州市科技发展计划项目(20150633B38)。

摘　　要：目的:观察养肺益肾颗粒治疗肺肾气阴两虚证慢性阻塞性肺疾病(COPD)稳定期的临床疗效及对患者血清单核细胞趋化蛋白-1(MCP-1)、白细胞介素-2(IL-2)、白细胞介素-10(IL-10)水平的影响。方法:选取60例肺肾气阴两虚证COPD稳定期患者,按随机数字表法分为中药组、西药组与对照组,每组20例。对照组给予常规治疗,西药组和中药组在对照组基础上分别给予茶碱缓释片和养肺益肾颗粒治疗,3组均治疗28 d。比较3组治疗前后中医证候积分,血清MCP-1、IL-2、IL-10水平及临床疗效。结果:治疗后,3组中医证候总分均较治疗前降低(P<0.01);中药组中医证候总分低于西药组、对照组(P<0.01)。治疗后,3组咳嗽积分均较治疗前降低(P<0.01);3组间咳嗽积分比较,差异有统计学意义(P<0.05),且中药组咳嗽积分低于对照组(P<0.05)。3组胸闷积分均较治疗前降低(P<0.01)。治疗后,3组血清IL-2、IL-10水平均较治疗前升高(P<0.05),血清MCP-1水平均较治疗前降低(P<0.05);中药组IL-2水平高于西药组、对照组(P<0.05),IL-10水平高于对照组(P<0.05),MCP-1水平低于西药组、对照组(P<0.05)。中药组总有效率为90.00%,西药组总有效率为65.00%,对照组总有效率为50.00%。3组间比较,差异有统计学意义(P<0.05),且中药组总有效率高于对照组(P<0.05)。结论:养肺益肾颗粒可改善肺肾气阴两虚证COPD稳定期患者的临床症状,调节其细胞因子水平。Objective:To observe the clinical effect of Yangfei Yishen granules in treatment of chronic obstructive pulmonary disease(COPD)with syndrome of qi-yin deficiency in lung and kidney at stable stage,and its effect on levels of monocyte chemoattractant protein-1(MCP-1),interleukin-2(IL-2),and interleukin-10(IL-10)in serum.Methods:A total of60 cases of COPD patients with syndrome of qi-yin deficiency in lung and kidney at stable stage were selected and divided into the Chinese medicine group,the western medicine group and the control group according to the random number table method,20 cases in each group.The control group was given routine treatment,the western medicine group and the Chinese medicine group were additionally given theophylline sustained-release tablets and Yangfei Yishen granules respectively based on the control group.All groups were treated for 28 days.Clinical effect and levels of MCP-1,IL-2 and IL-10 in serum as well as the scores of Chinese medicine syndrome before and after treatment in the three groups were compared.Results:After treatment,the score of Chinese medicine syndrome in the three groups were decreased when compared with those before treatment(P<0.01);the scores of Chinese medicine syndrome in the Chinese medicine group were lower than those in the western medicine group and the control group(P<0.01).After treatment,the scores of cough in the three groups were decreased when compared with those before treatment(P<0.01);the comparison of the cough scores among the three groups showed significance in the difference(P<0.05),and the score in the Chinese medicine group was lower than that in the control group(P<0.05).After treatment,the scores of chest distress in the three groups were decreased when compared with those before treatment(P<0.01).After treatment,levels of IL-2 and IL-10 in serum in the three groups were increased when compared with those before treatment(P<0.05),level of MCP-1 in serum in the three groups were decreased when compared with those before treatment(P<0.05);leve

关 键 词：慢性阻塞性肺疾病 稳定期 肺肾气阴两虚证 养肺益肾颗粒 中医证候 单核细胞趋化蛋白-1 白细胞介素-2 白细胞介素-10 

分 类 号：R563[医药卫生—呼吸系统] R256.14[医药卫生—内科学]