创伤膏联合负压封闭引流技术治疗慢性溃疡临床研究  

Clinical Study on Wound Care Ointment Combined with Vacuum Sealing Drainage for Chronic Ulcer

作　　者：蒋中华 费建华 JIANG Zhonghua;FEI Jianhua

机构地区：[1]海宁市第二人民医院,浙江海宁314419 [2]湖州市吴兴区中西医结合医院,浙江湖州313000

出　　处：《新中医》2021年第9期68-71,共4页New Chinese Medicine

摘　　要：目的:观察创伤膏联合负压封闭引流技术(VSD)治疗慢性溃疡的临床疗效。方法:选取86例慢性溃疡患者,按照随机数字表法分为对照组和观察组各43例。对照组给予VSD治疗,VSD撤退后予以常规换药,观察组在VSD撤退后予以创伤膏外敷,2组均治疗2个月。比较2组治疗前后McGill疼痛评分、炎症因子水平;比较2组溃疡愈合时间、住院时间及临床疗效。结果:治疗后,2组疼痛分级指数(PRI)感觉分、PRI情感分、视觉模拟评分法(VAS)评分、现有疼痛强度(PPI)评分均较治疗前降低(P<0.05),观察组PRI感觉分、PRI情感分、VAS评分、PPI评分均低于对照组(P<0.05)。观察组总有效率为90.70%,高于对照组的72.09%(P<0.05)。治疗后,2组血清肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平均较治疗前降低(P<0.05),观察组血清TNF-α、CRP、IL-6水平均低于对照组(P<0.05)。观察组溃疡愈合时间、住院时间均短于对照组(P<0.05)。结论:创伤膏联合VSD治疗慢性溃疡,可有效缓解患者的疼痛感,减轻炎症反应,促进溃疡愈合,缩短住院时间。Objective:To observe the clinical effect of wound care ointment combined with vacuum sealing drainage(VSD)for chronic ulcer.Methods:A total of 86 cases of patients with chronic ulcer were selected and divided into the control group and the observation group according to random number table method,43 cases in each group.After VSD,the control group was given routine dressing change,and the observation group was given external application of wound care ointment.Both groups were treated for two months.The score of McGill pain questionnaire and levels of inflammatory factors before and after treatment were compared between the two groups.Healing time of ulcer,hospitalization time and clinical effect were compared between the two groups.Results:After treatment,scores of sensory section and affective section in Pain Rating Index(PRI),as well as scores of Visual Analogue Scale(VAS)and present pain intensity(PPI)in the two groups were decreased when compared with those before treatment(P<0.05);the four scores above in the observation group were lower than those in the control group(P<0.05).The total effective rate was 90.70% in the observation group,higher than that of 72.09% in the control group(P<0.05).After treatment,levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the three levels in the observation group were lower than those in the control group(P<0.05).The healing of ulcer and hospitalization time in the observation group were shorter than those in the control group(P<0.05).Conclusion:The therapy of wound care ointment combined with VSD for chronic ulcer can effectively relieve pain and inflammatory response,promote the healing of ulcer and shorten hospitalization time.

关 键 词：慢性溃疡 负压封闭引流技术 创伤膏 疼痛 炎症因子 溃疡愈合时间 住院时间 

分 类 号：R632.1[医药卫生—外科学]