圆齿野鸦椿中的1个新木脂素  

A new lignan from Euscaphis konishii

作　　者：陈景新 倪林[1,2] 张耀 傅佳蕊 黄维 邹双全 CHEN Jing-xin;NI Lin;ZHANG Yao;FU Jia-rui;HUANG Wei;ZOU Shuang-quan(College of Plant Protection,Fujian Agriculture and Forestry University,Fuzhou 350002,China;Fujian Colleges and Universities Engineering Research Institute of Conservation&Utilization of Natural Bioresources,Fuzhou 350002,China)

机构地区：[1]福建农林大学植物保护学院,福建福州350002 [2]自然生物资源保育利用福建省高校工程研究中心,福建福州350002

出　　处：《中国中药杂志》2021年第8期2072-2078,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31700292);福建省科技特派员专项(103/KTP19108A,103/K1517070A)。

摘　　要：利用硅胶柱色谱、凝胶柱色谱、制备型高效液相色谱等分离技术,对具有抗肝癌活性的圆齿野鸦椿枝条Fr.6提取物进行分离纯化,从中分离得到12个木脂素类化合物。利用现代波谱学手段对化学成分进行结构鉴定,分别鉴定为konilignan(1),(7S,8R)-二氢脱氢二松柏醇9-O-D-吡喃葡萄糖苷(2),illiciumlignan B(3),苏式-1-(4-羟基-3-甲氧基苯基)-2[4-(4′-羟丙基)-2′-甲氧基苯氧基]-1,3-丙二醇(4),赤式-1-(4-羟基-3-甲氧基苯基)-2[4-(4′-羟丙基)-2′-甲氧基苯氧基]-1,3-丙二醇(5),罗汉松脂素(6),荛花酚(7),异落叶松脂素(8),(+)-南烛木树脂酚(9),4-ketopinoresinol(10),丁香脂素(11),vladinol D(12)。其中,化合物1为新的木脂素类化合物。抗肝癌活性结果显示:化合物10和化合物12对人肝癌HepG2细胞具有中等的抑制活性,IC50分别为107.12,183.56μmol·L-1。The chemical constituents from the extract of the twigs of Euscaphis konishii with anti-hepatoma activity were investigated,twelve compounds by repeated chromatography with silica gel,Sephadex LH-20 and preparative-HPLC.The structures of the chemical components were elucidated by spectroscopy methods,as konilignan(1),(7R,8S)-dihydrodehydrodico-niferylalcohol-9-O-β-D-glucopyranoside(2),illiciumlignan B(3),threo-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-panediol(4),erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-panediol(5),matairesinol(6),wikstromol(7),isolariciresinol(8),(+)-lyoniresinol(9),4-ketopinoresinol(10),syringaresin(11),and vladinol D(12).Among them,compound 1 is a new lignan.Compounds 10 and 12 had moderate inhibitory activity on HepG2 cells,with IC50 values of 107.12μmol·L-1 and 183.56μmol·L-1,respectively.

关 键 词：圆齿野鸦椿 化学成分 木脂素 konilignan 抗肝癌活性 

分 类 号：R284[医药卫生—中药学]