益生菌调控肠道屏障功能预防家禽球虫病的研究进展  

Advances in prevention of chicken coccidiosis by probiotics regulating intestinal barrier

作　　者：焦宇洲 于江旭 高东阳 王颢然 蔡旭旺[1] Yuzhou Jiao;Jiangxu Yu;Dongyang Gao;Haoran Wang;Xuwang Cai(State Key Laboratory of Agricultural Microbiology,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,Hubei Province,China)

机构地区：[1]华中农业大学动物医学院,农业微生物学国家重点实验室,湖北武汉430070

出　　处：《微生物学报》2021年第5期1064-1072,共9页Acta Microbiologica Sinica

基　　金：国家重点研发计划(2016YFD0501607);中央高校基本科研业务费专项基金(2020BC208)。

摘　　要：球虫病给养禽业带来巨大经济损失,人们对绿色健康食品的迫切需求使球虫病的防控面临新的挑战。伴随世界“禁抗”进程的不断推进,家禽养殖业亟需一种安全有效的新型抗球虫方法。益生菌可竞争性排斥病原菌定殖以防止球虫病继发感染,可刺激宿主抗菌肽、黏蛋白和紧密连接蛋白的分泌以抵御球虫入侵,还可激活免疫反应以增强机体抗球虫感染的能力。本文从调控肠道微生物群、改善肠黏膜屏障和调节免疫系统功能等方面综述了益生菌在预防和控制家禽球虫病中的作用,以期为高效抗球虫益生菌制剂的研发提供参考。Coccidiosis brings great economic loss to the poultry industry.The urgent need of green and healthy feed makes the prevention and control of coccidiosis face new challenges.In recent years,a safe and effective new anticoccidial method is needed by the poultry farming,owing to increasing bans of anticoccidial drugs.Recent researches have demonstrated probiotics can prevent coccidiosis-induced secondary infection by competitively excluding colonization of pathogens bacteria and stimulate the secretion of host antibacterial peptides,mucins and tight junction proteins to resist coccidiosis.In addition,it can enhance the anti-coccidial ability by activating the immune response.This review summarizes what is currently known on mechanisms about how probiotics prevent and control coccidiosis by modulating the gut microbiota,ameliorating mucus barrier,affecting function of immune system,to provide a reference for the development of probiotic products to control coccidiosis.

关 键 词：球虫病 益生菌 肠道屏障 

分 类 号：S858.3[农业科学—临床兽医学]