异维A酸联合舒敏保湿特护霜治疗重度痤疮的疗效  

Clinical effects of isotretinoin combined with anti-sensitive moisturizing tolerance-extreme cream on severe acne

作　　者：盛安琪 陈惠英[1] 欧阳杰[1] 许爱娥[1] Sheng Anqi;Chen Huiying;Ouyang Jie;Xu Ai'e(Department of Dermatology,Hangzhou Third People's Hospital,Hangzhou 310009,China)

机构地区：[1]杭州市第三人民医院皮肤科,杭州310009

出　　处：《中华医学美学美容杂志》2021年第2期139-144,共6页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：国家自然科学基金(81773335、81803131、81602755);浙江省自然科学基金(LY18H110001);浙江省基础公益研究计划(LGF18H110002)。

摘　　要：目的观察舒敏保湿特护霜联合异维A酸治疗重度痤疮的疗效.方法2018年11月至2019年7月,收集在杭州第三人民医院皮肤科痤疮专病门诊治疗的重度痤疮患者50例,随机数字表法分为试验组25例[男9例,女16例,年龄16~35(22.17±3.94)岁];对照组25例[男11例,女14例,年龄19~35(22.43±3.87)岁].试验组口服异维A酸联合舒敏保湿特护霜治疗,对照组单用口服异维A酸治疗.治疗前和治疗56 d后进行角质层含水量(SCH)、经皮失水量(TEWL)、皮肤生理指标等检测.结果治疗56 d后,对照组TEWL为15.75±3.31,SCH为10.13±3.62;试验组TEWL为12.17±3.61,SCH为28.07±3.17,两组比较差异有统计学意义(t值分别为3.610、12.398,P分别为0.002、0.000).试验组囊肿结节体积、瘢痕凹陷体积和深度、皮肤粗糙度、红斑绝对值和区域显著低于对照组(t值分别为2.280、1.676、2.332、1.508、4.813、3.637,P分别为0.031、0.011、0.027、0.040、0.000、0.001).结论异维A酸联合舒敏保湿特护霜治疗重度痤疮有较好的疗效,且能降低屏障破坏等不良反应.Objective To observe the efficacy of anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin in the treatment of severe acne.Methods Fifty patients with severe acne were selected in the Dermatology Clinic of the Third People's Hospital of Hangzhou from November 2018 to July 2019.They were randomly divided into the experimental group of 25 cases and the control group of 25 cases.The experimental group was treated with anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin orally.The control group was treated with isotretinoin orally alone.Before and after treatment for 56 days,lactate score,skin cuticle hydration(SCH),transepidermal water loss(TEWL)and skin physiological indexes were measured.Results After 56 days of treatment,the TEWL and SCH of the control group were 15.75±3.31 and 10.13±3.62,the TEWL and SCH of the experimental group were 12.17±3.61 and 28.07±3.17,respectively;the difference was statistically significant(T was 3.610 and 12.398,P was 0.002 and 0.000,respectively).The volume and depth of cyst nodule,scar depression,skin roughness,absolute value and area of erythema in the experimental group were significantly lower than those in the control group(T was 2.280,1.676,2.332,1.508,4.813 and 3.637;P was 0.031,0.O11,0.027,0.040,0.000 and 0.001,respectively).Conclusions Anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin has a good effect on severe acne and it can reduce the barrier damage and other adverse reactions.

关 键 词：异维A酸 重度痤疮 舒敏保湿特护霜 皮肤生理指标 检测 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]