IL-1β、ET-1在重型脑外伤术后脑梗死中的研究  

Investigation of IL-1βand ET-1 in post-traumatic cerebral infarction in patients with severe traumatic brain injury

作　　者：王德林 汪艳[1] 邱政[1] 陈晟[1] 郑绍俭 熊建平[1] 张晓东 周叶军 WANG Delin;WANG Yan;QIU Zheng(The First People's Hospital of Jiande,Zhejiang 311600,China)

机构地区：[1]浙江省建德市第一人民医院,建德311600

出　　处：《浙江创伤外科》2021年第3期407-409,共3页Zhejiang Journal of Traumatic Surgery

摘　　要：目的探讨白细胞介素-1β(IL-1β)、内皮素-1(ET-1)在重型创伤性脑损伤(TBI)术后脑梗死患者体内的表达情况。方法选取本院2016年11月至2019年11月神经外科收治的重型TBI术后脑梗死的患者60例作为试验组,选择本院体检中心健康志愿者40例为对照组。分析比较两组患者一般资料,包括性别、年龄、受伤原因、受伤距手术时间以及Glasgow昏迷评分;比较两组患者1、3、7天体温、红细胞压积(Hct)、血沉(ESR)、纤维蛋白原等指标变化;比较两组患者各时间点外周血清神经元特异性烯醇化酶(NSE)和ET-1、外周血C反应蛋白(CRP)与细胞因子IL-1β水平等。结果两组间一般临床资料差异无统计学意义(P>0.05);试验组患者体温、Hct、ESR、纤维蛋白原在第1、3、7天均明显高于对照组各时间点对应值(P<0.05);试验组患者外周血NSE与ET-1、在第1、3、7天均明显高于对照组各时间点对应值(P<0.05);试验组患者外周血清CRP与细胞因子IL-1β均明显高于对照组(P<0.05)。结论重型创伤性脑损伤术后脑梗死患者体内出现了IL-1β、ET-1明显的高表达。Objective To investigate the expression of IL-1βand ET-1 in patients with traumatic cerebral infarction after severe traumatic brain injury(TBI).Methods 60 patients with traumatic cerebral infarction after severe TBI surgery admitted to neurosurgery department of our hospital from November 2016 to November 2019 were selected as the experimental group,and 40 healthy volunteers in the physical examination center of our hospital were selected as the control group.The general information of the two groups was analyzed and compared,including gender,age,injury cause,time between injury and operation,and GCS score.The changes of body temperature,Hct,ESR,fibrinogen and other indicators at three time points(1d,3d,7d)were compared between the two groups.The levels of peripheral blood NSE and ET-1,peripheral blood CRP and cytokine IL-1βin the two groups were compared at each time point.Results Tthere was no significant difference in general clinical data between the two groups(P>0.5).The body temperature,Hct,ESR,and fibrinogen of the test group were significantly higher than those of the control group on at day 1,day 3,and day 7(P<0.05).Peripheral blood NSE,ET-1 in the test group were significantly higher than those in the control group on at day 1,3d and 7d(P<0.05).The serum CRP and cytokineIL-1βlevels in the peripheral blood of the experimental group were significantly higher than those in the control group(P<0.05).Conclusion Significant high expression of IL-1βand ET-1 was observed in patients with traumatic cerebral infarction after severe traumatic brain injury(TBI).

关 键 词：重型创伤性脑损伤 脑梗死 IL-1Β ET-1 

分 类 号：R651.1[医药卫生—外科学]