利托君与硫酸镁治疗胎膜早破型先兆早产的临床疗效  

Clinical efficacy of ritodrine and magnesium sulfate in the treatment of threatened premature delivery with premature rupture of membranes

作　　者：姬力群 盛晓滨[1] 林经萍 梁丽丽 JI Li-qun;SHENG Xiao-bin;LIN Jing-ping(Shijingshan Hospital,Beijing 100043,China)

机构地区：[1]北京市石景山医院,100043

出　　处：《中国实用医药》2021年第16期7-10,共4页China Practical Medicine

摘　　要：目的分析胎膜早破型先兆早产孕产妇采用利托君与硫酸镁治疗的临床疗效。方法92例胎膜早破型先兆早产孕产妇,按照治疗方法不同分为对照组和观察组,每组46例。观察组采用利托君联合硫酸镁治疗,对照组采用单一硫酸镁治疗。比较两组治疗前后纤维连接蛋白(FFN)、宫颈管长度及分娩情况、不良妊娠结局发生情况、新生儿Apgar评分。结果治疗后,观察组FFN(27.61±4.28)ng/ml明显低于对照组的(38.57±5.04)ng/ml,宫颈管长度(2.76±0.38)cm明显长于对照组的(2.31±0.34)cm,差异均有统计学意义(P<0.05)。观察组孕周长于对照组,宫缩时间、分娩时间短于对照组,差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率为2.17%,明显低于对照组的15.22%,差异具有统计学意义(P<0.05)。观察组新生儿Apgar评分为(9.05±0.72)分,明显高于对照组的(8.64±0.95)分,差异具有统计学意义(t=2.333,P=0.022<0.05)。结论对于胎膜早破型先兆早产孕产妇,临床采用利托君与硫酸镁联合治疗,能够有效延长孕周,减少不良妊娠结局,提高新生儿预后质量,治疗效果显著,可在临床广泛应用。Objective To analyze the clinical efficacy of ritodrine and magnesium sulfate in the treatment of threatened premature delivery with premature rupture of membranes.Methods A total of 92 cases of threatened premature delivery with premature rupture of membranes were divided into control group and observation group according to different treatment methods,with 46 cases in each group.The observation group was treated with ritodrine and magnesium sulfate,and the control group was treated with magnesium sulfate.The fetal fibronectin(FFN)and cervical canal length before and after treatment,condition of delivery,occurrence of adverse pregnancy outcome,neonatal Apgar score were compared between the two groups.Results After treatment,the FFN(27.61±4.28)ng/ml of the observation group was obviously lower than(38.57±5.04)ng/ml of the control group,and cervical canal length(2.76±0.38)cm was obviously longer than(2.31±0.34)cm of the control group.All the difference was statistically significant(P<0.05).The gestational weeks of the observation group was longer than that of the control group,and uterine contraction time,delivery time were shorter than those of the control group.All the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcome of the observation group was 2.17%,which was obviously lower than 15.22%of the control group,and the difference was statistically significant(P<0.05).The neonatal Apgar score of the observation group was(9.05±0.72)points,which was obviously higher than(8.64±0.95)points of the control group,and the difference was statistically significant(t=2.333,P=0.022<0.05).Conclusion Combination of ritodrine and magnesium sulfate shows significant therapeutic effect on threatened premature delivery with premature rupture of membranes,which can effectively prolong the gestational weeks,reduce the adverse pregnancy outcome,improve neonatal prognosis.It can be widely used in clinic.

关 键 词：利托君 硫酸镁 胎膜早破 先兆流产 治疗效果 

分 类 号：R714.21[医药卫生—妇产科学]