尘螨过敏性变应性鼻炎儿童肺功能异常的危险因素分析  

Risk factors analysis of abnormal lung function in children with dust mite allergic rhinitis

作　　者：容嘉妍[1] 王桂兰[1] 刘翔腾[1] 黄娟[1] 陈昂[1] 林嘉镖[1] 魏可英 RONG Jia-yan;WANG Gui-lan;LIU Xiang-teng;HUANG Juan;CHEN Ang;LIN Jia-biao;WEI Ke-ying(Department of Pediatrics,Zhongshan Bo′ai Hospital Affiliated to Southern Medical University,Guangdong Province,Zhongshan 528400,China)

机构地区：[1]南方医科大学附属中山市博爱医院儿科,广东中山528400

出　　处：《中国当代医药》2021年第16期8-11,16,共5页China Modern Medicine

基　　金：广东省中山市第一批社会公益与基础研究项目(医疗卫生)(2020B1047)。

摘　　要：目的探讨尘螨过敏性变应性鼻炎(AR)儿童肺功能异常的危险因素。方法选取2019年11月~2020年4月于南方医科大学附属中山市博爱医院儿科门诊就诊的128例确诊为尘螨过敏导致AR且无哮喘患儿作为研究对象,根据是否存在肺功能异常将其分为肺功能异常组(40例)和正常组(88例),并分析肺功能异常与性别、年龄、血清免疫球蛋白E(IgE)水平、尘螨特异性IgE(sIgE)水平、过敏原种类数的相关性。结果单因素分析结果显示,肺功能异常组和正常组患儿的病程、症状发作时间、严重程度比较,差异有统计学意义(P<0.05)。多因素分析结果显示,病程3~5年(β=1.186,OR=3.273,95%CI=1.123~9.536)、病程>5年(β=1.551,OR=4.714,95%CI=1.374~16.175)、症状严重程度中重度(β=1.531,OR=4.625,95%CI=1.303~16.414)、症状持续性发作(β=1.019,OR=2.769,95%CI=1.144~6.701)是肺功能异常的影响因素(P<0.05)。结论部分尘螨过敏性AR儿童已存在肺功能异常,持续性发作、中重度、病程长的患儿出现肺功能异常的概率更高,肺功能异常与IgE水平、sIgE水平、过敏原种类数无明显关联。Objective To investigate the risk factors of abnormal lung function in children with dust mite allergic rhinitis(AR).Methods A total of 128 children with dust mite AR without asthma who were diagnosed in the Department of Pediatrics in Zhongshan Bo′ai Hospital Affiliated to Southern Medical University from November 2019 to April 2020 were selected as the research objects.Patients were divided into abnormal pulmonary function group(40 cases)and normal group(88 cases)according to the results of pulmonary function.The relation between abnormal lung function and gender,age,total immunoglobulin E(IgE)levels,dust mite specific IgE(sIgE)levels and the number of allergens were analyzed.Results Univariate analysis results showed that there were significant differences in the course of disease,onset time and severity of symptoms between the abnormal pulmonary function group and the normal group(P<0.05).Multivariate analysis showed that the course of disease was 3-5 years(β=1.186,OR=3.273,95%CI=1.123-9.536),the course of disease was 5 years(β=1.551,OR=4.714,95%CI=1.374-16.175),and the severity of symptoms was moderate and severe(β=1.531,OR=4.625,95%CI=1.303-16.414)and persistent onset of symptoms(β=1.019,OR=2.769,95%CI=1.144-6.701)were the influential factors of abnormal lung function(P<0.05).Conclusion Some children with dust mite AR have abnormal lung function.Children with long course,persistent,moderate-severe AR are higher probability to have abnormal lung function.There are no significant correlation between abnormal lung function and total IgE levels,sIgE levels and the number of positive SPTs.

关 键 词：变应性鼻炎 肺功能 危险因素 儿童 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]