单采新鲜冰冻血浆在制备冷沉淀凝血因子中的应用  

Application of apheresis fresh frozen plasma in preparation of cryoprecipitated coagulation factor

作　　者：卢少芬 杜明仪 张琦 黎淑怡 梁荧 LU Shao-fen;DU Ming-yi;ZHANG Qi;LI Shu-yi;LIANG Ying(Zhaoqing Central Blood Station,Guangdong Province,Zhaoqing 526040,China)

机构地区：[1]广东省肇庆市中心血站,广东肇庆526040

出　　处：《中国当代医药》2021年第16期40-42,共3页China Modern Medicine

基　　金：广东省肇庆市科技创新计划项目(2014E2813)。

摘　　要：目的探讨单采新鲜冰冻血浆在制备冷沉淀凝血因子中的应用效果。方法选取2020年4~10月肇庆市中心血站采集的48袋血浆,采用随机数字表法分为实验组(24袋)与对照组(24袋)。实验组采用单采新鲜冰冻血浆制备冷沉淀凝血因子、对照组采用全血制备的新鲜冰冻血浆制备冷沉淀凝血因子,比较两组冷沉淀凝血因子中的Ⅷ因子(FⅧ)含量、纤维蛋白原(Fg)含量以及冷沉淀凝血因子合格率。结果实验组FⅧ含量高于对照组,差异有统计学意义(P<0.05);两组的Fg含量比较,差异无统计学差异(P>0.05);实验组冷沉淀凝血因子合格率高于对照组,差异有统计学意义(P<0.05)。结论单采新鲜冰冻血浆在制备冷沉淀凝血因子中的应用价值较高,所得凝血因子活性更好,质量更佳。Objective To explore the application effect of apheresis fresh frozen plasma in preparation of cryoprecipitated coagulation factor.Methods A total of 48 bags of plasma collected from Zhaoqing Central Blood Station from April to October 2020 were selected and divided into experimental group(24 bags)and control group(24 bags)according to the random number table method.The experimental group used apheresis fresh frozen plasma to prepare cryoprecipitated coagulation factor,and the control group used fresh frozen plasma prepared from whole blood to prepare cryoprecipitated coagulation factor.The content of factorsⅧ(FⅧ),the fibrinogen(Fg)content,and the pass rate of cryoprecipitated coagulation factor were compared between the two groups.Results The FⅧcontent in the experimental group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in Fg content between the two groups(P>0.05).The pass rate of cryoprecipitated coagulation factor in experimental group was higher than that in control group,the difference was statistically significant(P<0.05).Conclusion The application of apheresis fresh frozen plasma in preparation of cryoprecipitated coagulation factor is valuable,the activity and the quality of coagulation factor is better.

关 键 词：单采新鲜冰冻血浆 冷沉淀凝血因子 纤维蛋白原 合格率 

分 类 号：R446.11[医药卫生—诊断学]