环孢素A联合丙种球蛋白治疗重型再生障碍性贫血的效果和安全性  

Efficacy and safety of Cyclosporin A combined withγGlobulin in the treatment of severe aplastic anemia

作　　者：李丽美 LI Li-mei(Department of Hematology,Liaoning Provincial People′s Hospital,Liaoning Province,Shenyang 110000,China)

机构地区：[1]辽宁省人民医院血液内科,辽宁沈阳110000

出　　处：《中国当代医药》2021年第16期57-59,63,共4页China Modern Medicine

摘　　要：目的分析环孢素A联合丙种球蛋白治疗重型再生障碍性贫血的效果和安全性。方法选取2018年1月~2019年12月辽宁省人民医院血液内科收治的62例重型再生障碍性贫血患者作为研究对象,采用奇偶分组法将其分为对照组(31例)和观察组(31例)。对照组患者采用环孢素A治疗,观察组患者采用环孢素A联合丙种球蛋白治疗。比较两组患者的临床效果、安全性、各项生化指标、辅助/诱导T淋巴细胞(CD4)、辅助/诱导T抑制细胞(CD8)以及T辅助细胞/T抑制细胞比值(CD4/CD8)水平。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者的治疗安全性比较,差异无统计学意义(P>0.05);观察组患者的血红蛋白(Hb)、红细胞(RBC)、外周血网织红细胞(RC)、白细胞(WBC)、嗜中性粒细胞绝对计数(ANC)、血小板(PLT)水平高于对照组,差异有统计学意义(P<0.05);观察组患者的CD4、CD4/CD8水平高于对照组,差异有统计学意义(P<0.05);观察组的CD8水平低于对照组,差异有统计学意义(P<0.05)。结论重型再生障碍性贫血患者接受环孢素A联合丙种球蛋白治疗,能够有效改善患者的脊髓造血功能,使贫血症状得到明显的减轻,具有良好的临床效果,且治疗期间的安全性较高,值得在临床上推广应用。Objective To analyze the efficacy and safety of cyclosporin A combined withγglobulin in the treatment of severe aplastic anemia.Methods Sixty-two patients with severe aplastic anemia admitted to the Department of Hematology,Liaoning Provincial People′s Hospital from January 2018 to December 2019 were selected as the research subjects.They were divided into control group(n=31)and observation group(n=31)by odd/even number method.Patients in the control group were treated with Cyclosporin A,and patients in the observation group were treated with Cyclosporin A combined withγGlobulin.The clinical efficacy,safety,biochemical indexes,helper/inducible T lymphocytes(CD4),helper/inducible T suppressor cells(CD8)and ratio of T helper cells to T suppressor cells(CD4/CD8)between the two groups were compared.Results The total effective rate of observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The difference of the treatment safety between the two groups was not statistically significant(P>0.05).The levels of the hemoglobin(Hb),red blood cell(RBC),peripheral reticulocyte(RC),white blood cell(WBC),absolute neutrophil count(ANC),platelet(PLT)in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).The levels of CD4 and CD4/CD8 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The level of CD8 in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with severe aplastic anemia,combination of Cyclosporine A andγGlobulin can effectively improve the spinal cord′s hematopoietic function and greatly alleviate anemia in a favorable clinical effect.The safety is high during treatment,which is worthy of clinical promotion and application.

关 键 词：重型再生障碍性贫血 环孢素A 丙种球蛋白 生化指标 

分 类 号：R556.5[医药卫生—血液循环系统疾病]