椎管内麻醉与Apelin对血压和血糖影响的研究进展  

Research progress on effect of spinal anesthesia and Apelin on blood pressure and blood glucose

作　　者：崔海英 范俊柏[1] 马瑞英 温苗苗 Cui Haiying;Fan Junbai;Ma Ruiying;Wen Miaomiao(Department of Anesthesiology,the Second Hospital of Shanxi Medical University,Taiyuan 031001,China)

机构地区：[1]山西医科大学第二医院麻醉科,太原031001

出　　处：《新医学》2021年第6期404-407,共4页Journal of New Medicine

基　　金：山西省应用基础研究项目(201701D121139)。

摘　　要：椎管内麻醉由于阻滞了交感神经,故能抑制机体对手术牵拉等刺激的应激反应,同时肾上腺皮质激素、甲状腺素、儿茶酚胺等分泌均减少,血糖也会出现波动。交感神经阻滞会引起外周静脉血管扩张,回心血量减少,导致血压降低。Apelin是血管紧张素Ⅱ1型受体相关蛋白(APJ)的内源性配体,在体内分布广泛,在许多器官和组织中通过不同的方式参与血压和血糖的调节。Apelin在糖尿病、高血压等代谢综合征的发生发展中起着重要作用。该文就Apelin的功能及椎管内麻醉下Apelin与血压和血糖的关系进行了综述。Spinal anesthesia can inhibit the stress response of the body to surgical pulling and other stimulation due to the blockage of the sympathetic nerve.Meantime,it can also reduce the secretion of adrenal cortical hormone,thyroxine and catecholamine,and lead to the fluctuations of the blood glucose level.Sympathetic block can induce the dilatation of peripheral veins,decrease the blood return and lead to hypotension.As an endogenous ligand of angiotensinⅡtype 1 receptor-associated protein(APJ),Apelin is widely distributed in the body and involved in the regulation of blood pressure and blood glucose in multiple organs and tissues in different patterns.Apelin plays a critical role in the incidence and development of metabolic syndromes,such as diabetes mellitus and hypertension,etc.In this article,the function of Apelin and the relationship between Apelin and blood pressure and blood glucose under subarachnoid anesthesia were reviewed.

关 键 词：椎管内麻醉 APELIN 血压 血糖 

分 类 号：R614[医药卫生—麻醉学]