生脉注射液治疗尘肺病合并肺源性心脏病患者疗效观察  

Clinical observation on the curative effect of Shengmai injection on pneumoconiosis complicated with pulmonary heart disease

作　　者：田秀丽 侯利萍 贾仲芬 莘翼祥 方庆娟 张华 温玉萍 TIAN Xiuli;HOU Liping;JIA Zhongfen;XIN Yixiang;FANG Qingjuan;ZHANG Hua;WEN Yuping(Zhangjiakou First Hospital, Zhangjiakou 075000, Hebei,China)

机构地区：[1]张家口市第一医院,河北张家口075000

出　　处：《现代中西医结合杂志》2021年第17期1862-1866,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：张家口市科学技术局2018课题计划项目(1821097D)。

摘　　要：目的探讨生脉注射液治疗尘肺病合并肺源性心脏病(肺心病)患者的临床疗效。方法选取张家口市第一医院2011年1月—2017年12月呼吸内科住院部收治的尘肺病合并肺心病患者200例作为研究对象,随机分为2组各100例。对照组采用常规治疗,实验组在对照组基础上加用生脉注射液治疗,14 d为1个疗程。治疗前后分别测定2组患者第1秒用力呼气量(FEV_(1))、用力肺活量(FVC)、动脉血二氧化碳分压[p(CO_(2))]、动脉血氧分压[p(O_(2))]、右心室收缩末期容积(RVESV)、右心室舒张末期容积(RVEDV)、右心室每搏量(RVSV)和右心室射血分数(RVEF)、肺动脉收缩压(PASP),统计比较2组治疗效果及不良反应发生情况。结果治疗后,2组FEV_(1)、FVC、p(O_(2))、RVSV、RVEF均较治疗前明显增高(P均<0.05),p(CO_(2))、RVESV、RVEDV、PASP均较治疗前明显降低(P均<0.05),实验组各指标改善幅度较对照组更明显(P均<0.05)。实验组治疗总有效率为88%(88/100),明显高于对照组的71%(71/100),差异有统计学意义(P<0.05)。2组药物不良反应率比较差异无统计学意义(P>0.05)。结论生脉注射液治疗尘肺病合并肺心病患者有利于明显改善心肺功能,临床疗效满意,且安全。Objective It is to explore the clinical efficacy of Shengmai injection in the treatment of pneumoconiosis complicated withpulmonary heart disease.Methods A total of 200 patients with pneumoconiosis and pulmonary heart disease who were admitted to the inpatient department of the Department of Respiratory Medicine in Zhangjiakou First Hospital from January 2011 to December 2017 were selected as the research objects,and they were randomly divided into 2 groups with 100 cases in each group.The control group was treated with conventional treatment,and the experimental group was treated with Shengmai injection on the basis of the control group,14 d was a course of treatment.Before and after treatment,the forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),partial pressure of arterial carbon dioxide[p(CO_(2))],partial pressure of arterial oxygen[p(O_(2))],right ventricular end-systolic volume(RVESV),right ventricular end-diastolic volume(RVEDV),right ventricular stroke volume(RVSV),right ventricular ejection fraction(RVEF),pulmonary artery systolic pressure(PASP)were detected,and the treatment effects and the occurrence of adverse reactions were observed and compared in the two groups.Results After treatment,FEV_(1),FVC,p(O_(2)),RVSV,and RVEF in the two groups were significantly higher than those before treatment(all P<0.05),and p(CO_(2)),RVESV,RVEDV and PASP were significantly lower than those before treatment(all P<0.05),the improvement of each index of the experimental group was more obvious than that of the control group(P<0.05).The total effective rate of treatment in the experimental group was 88%(88/100),which was significantly higher than 71%(71/100)in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the adverse drug reaction rate between the two groups(P>0.05).Conclusion Shengmai injection is beneficial to significantly improve cardiopulmonary function in the treatment of patients with pneumoconiosis and pulmonary hear

关 键 词：尘肺病 肺心病 生脉注射液 心功能 肺功能 

分 类 号：R135.2[医药卫生—劳动卫生] R541.5[医药卫生—公共卫生与预防医学]