Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells:Three case reports and review of literature  

作　　者：Hyunjun Ahn Sang Yeon Lee Won Ju Jung Kye-Ho Lee 

机构地区：[1]bio Beauty&Health Company(bBHC)-Stem Cell Treatment&Research Institute(STRI),Seoul 04420,South Korea [2]Department of Functional Genomics,University of Science and Technology KRIBB School,Deajeon 34113,South Korea [3]97.7 Beauty&Health(B&H)Clinics,Seoul 04420,South Korea

出　　处：《World Journal of Clinical Cases》2021年第15期3741-3751,共11页世界临床病例杂志

摘　　要：BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair loss.AA appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune diseases.For this reason,preclinical and case studies of AA and related diseases using MSCs have been conducted.CASE SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the scalp.She was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 mo.The AA gradually improved 3 mo after the first round.The patient was cured,and AA did not recur.Case 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the scalp.She was given two rounds of MM-UC-MSCs over 1 mo.The AA immediately improved after the first round.The patient was cured,and AA did not recur.Case 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 mo.Her hair began to grow about 3 mo after the first round.The patient was cured,and alopecia universalis did not recur.CONCLUSION MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases.

关 键 词：Alopecia areata Umbilical cord-derived mesenchymal stem cells ALLOGENIC Cell therapy Minimal manipulation Case report 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]