富血小板血浆对难治性皮肤溃疡创面愈合及肉芽组织中TGF-β_(1)及EGF表达的影响  

Effect of Platelet-rich Plasma on Wound Healing and Expression of TGF-β_(1) and EGF in Granulation Tissue of Refractory Skin Ulcer

作　　者：杨丽英 罗鹏 陈玲 YANG Li-ying;LUO Peng;CHEN Ling(Department of Burn and Plastic Surgery,the First People's Hospital of Ziyang,Ziyang 641300,Sichuan,China;Department of Radiology,the First People's Hospital of Ziyang,Ziyang 641300,Sichuan,China;Department of Gastroenterology,the First People's Hospital of Ziyang,Ziyang 641300,Sichuan,China)

机构地区：[1]资阳市第一人民医院烧伤整形科,四川资阳641300 [2]资阳市第一人民医院放射科,四川资阳641300 [3]资阳市第一人民医院消化内科,四川资阳641300

出　　处：《中国美容医学》2021年第5期48-51,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨富血小板血浆联合混合换药对难治性皮肤溃疡的治疗效果及其对肉芽组织中TGF-β_(1)及EGF表达的影响。方法:选择68例难治性皮肤溃疡患者,随机分为对照组和观察组,每组34例。两组患者均给予混合换药治疗,观察组另给予富血小板血浆凝胶治疗。治疗12周后评估两组患者临床疗效、创面愈合时间、创面愈合美学满意度;PRP治疗前及治疗后第7天、第14天比较两组患者创面肉芽组织中转化生长因子β_(1)(Transforming growth factor,TGF-β_(1))及表皮生长因子(Epidermal growth factor,EGF)表达水平。结果:观察组临床有效率为97.1%(33/34),对照组为73.5%(25/34),差异有统计学意义(P<0.05)。观察组创面愈合时间为(25.6±4.6)d短于对照组的(32.7±5.1)d,差异有统计学意义(P<0.05)。观察组创面愈合美容满意度为91.2%(31/34)高于对照组的67.6%(23/34),差异有统计学意义(P<0.05)。PRP治疗前两组肉芽组织中TGF-β_(1)及EGF表达水平比较差异无统计学意义(P>0.05);治疗后第7天、第14天两组患者创面肉芽组织中TGF-β_(1)及EGF表达水平均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:富血小板血浆联合混合换药能够提高难治性皮肤溃疡临床治疗效果,改善美学外观,其可能同上调肉芽组织中TGF-β_(1)及EGF的表达有关。Objective To investigate the clinical effect of platelet-rich plasma combined with dressing change on refractory skin ulcer and its effect on the expression of TGF-β_(1) and EGF in granulation tissue.Methods 68 patients with refractory skin ulcers were randomly divided into the control group and the observation group,34 cases in each group.Two groups of patients were given mixed dressing treatment.The observation group was treated with platelet rich plasma gel treatment.After 12 weeks treatment,the clinical efficacy,wound healing time,esthetic satisfaction of wound healing of two groups were evaluated.The expression levels of TGF-β_(1) and EGF in granulation tissue were compared before PRP treatment and on the 7 th and 14 th day after PRP treatment.Results The clinical effective rate of the observation group was 97.1%(33/34),and that of the control group was 73.5%(25/34),the difference was statistically significant(P<0.05).The wound healing time of the observation group was(25.6±4.6)d,which was shorter than that of the control group[(32.7±5.1)d,P<0.05].The satisfaction of the observation group was 91.2%(31/34),which was higher than that of the control group[67.6%(23/34),P<0.05].There was no significant difference in the expression of TGF-β_(1) and EGF between the two groups before PRP treatment(P>0.05).The expression levels of TGF-β_(1) and EGF in granulation tissue of two groups were increased on the 7 th and 14 th day after treatment,and the observation group was higher than that of the control group(P<0.05).Conclusion Platelet-rich plasma combined with dressing change can improve the clinical therapeutic effect and aesthetic appearance of refractory skin ulcer,which may be related to the up-regulation of the expression of TGF-β_(1) and EGF in granulation tissue.

关 键 词：富血小板血浆 难治性皮肤溃疡创面 创面修复 转化生长因子β_(1) 表皮生长因子 

分 类 号：R622[医药卫生—整形外科]