机械性创伤患者血液检测指标变化与血栓形成的因素分析  

Correlation analysis of blood test index changes and thrombosis in patients with mechanical trauma

作　　者：罗纯生 展秀君 沈忠达 沈萍[2] 吴媛媛[2] LUO Chunsheng;ZHAN Xiujun;SHEN Zhongda;SHEN Ping;WU Yuanyuan(Jiamusi Center Blood Station in Heilongjiang Province,Jiamusi 154000,China;Department of Clinical Laboratory,Jiamusi Hospital of Traditional Chinese Medicine in Heilongjiang Province,Jiamusi 154000,China)

机构地区：[1]黑龙江省佳木斯市中心血站,黑龙江佳木斯154000 [2]黑龙江省佳木斯市中医院检验科,黑龙江佳木斯154000

出　　处：《中国现代医生》2021年第13期13-16,共4页China Modern Doctor

摘　　要：目的探讨机械性创伤患者血液检测指标变化与血栓形成的因素。方法选择2018年4月至2019年3月我院收治的50例机械性创伤伴血栓形成患者作为观察组,50例健康体检志愿者作为对照组,对两组对象的特异性生长因子、血小板、凝血、抗凝、纤溶系统进行检查。结果观察组特异性生长因子、血小板数量分别为(3.62±0.34)U/mL、(179.41±52.32)×10^(9)/mL,与对照组(3.54±0.25)U/mL、(166.18±46.38)×10^(9)/mL比较,差异无统计学意义(P>0.05);观察组血小板聚集率为(67.58±21.33)%,高于对照组的(52.36±14.36)%,观察组血浆凝血酶原时间(9.24±1.23)s、凝血酶时间(21.89±1.26)s、抗凝血酶Ⅲ(68.93±15.66)%、纤溶酶原(74.68±16.33)%皆低于对照组血浆凝血酶原时间(11.65±1.22)s、凝血酶时间(25.68±1.54)s、抗凝血酶Ⅲ(96.42±11.54)%、纤溶酶原(89.47±15.64)%,观察组纤溶酶原激活物抑制物-1为(0.96±0.31)%,高于对照组的(0.63±0.19)%,差异有统计学意义(P<0.05)。结论机械性创伤患者的特异性生长因子和血小板数量基本不影响血栓的形成,但患者的血小板聚集率、血浆凝血酶原时间、凝血酶时间、特抗凝血酶Ⅲ、纤溶酶原、纤溶酶原激活物抑制物-1的含量变化都易影响血栓的形成。Objective To explore the correlation between the changes in blood test indexes and thrombosis in patients with mechanical trauma.Methods A total of 50 mechanical trauma patients with thrombosis from April 2018 to March 2019 were selected as the observation group,and 50 healthy physical examination volunteers who were admitted to our hospital as the control group at the same time.The specific growth factors,platelets,coagulation,anticoagulation,and fibrinolysis systems of the two groups were detected.Results There was no significant difference between the observation group and the control group in the specific growth factors[(3.62±0.34)U/mL vs.(3.54±0.25)U/mL]and the number of platelets[(179.41±52.32)×10^(9)/mL vs.(166.18±46.38)×10^(9)/mL],The difference was not statistically significant(P>0.05).The platelet aggregation rate of the observation group was(67.58±21.33)%,higher than(52.36±14.36)%of the control group.The plasma prothrombin time(9.24±1.23)s,thrombin time(21.89±1.26)s,antithrombinⅢ(68.93±15.66)%,plasminogen(74.68±16.33)%of the observation group were lower than those[(11.65±1.22)s,(5.68±1.54)s,(96.42±11.54)%,(89.47±15.64)%]of the control group.The plasminogen activator inhibitor-1(0.96±0.31)%was greater than(0.63±0.19)%in the control group.The two groups of subjects′index results were significantly different(P<0.05).Conclusion The specific growth factors and the number of platelets in patients with mechanical trauma does not affect the formation of thrombus.However,the patient′s platelet aggregation rate,plasma prothrombin time,thrombin time,antithrombinⅢ,plasminogen,and fibrinolysis,the changes in the content of zymogen activator inhibitor-1 easily affect the formation of thrombus.

关 键 词：机械性创伤 特异性生长因子 血小板 凝血 抗凝 纤溶系统 血栓 

分 类 号：R654.4[医药卫生—外科学]