针药并用对心绞痛患者血小板聚集率和心率变异性的影响  

Effect of Combined Acupuncture and Medicine on Platelet Aggregation Rate and Heart Rate Variability in Patients with Angina Pectoris

作　　者：刘贝贝 艾乐群[1] 林欢庆 LIU Bei-bei;AI Le-qun;LIN Huan-qing(Hunan College of Traditional Chinese Medicine First Hospital(Hunan Provincial Hospital of Traditional Chinese Medicine),Changsha 412000,China)

机构地区：[1]湖南中医药高等专科学校附属第一医院(湖南省直中医医院),长沙412000

出　　处：《上海针灸杂志》2021年第6期652-657,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：中医内科学省部共建教育部重点实验室开放课题(2YNK201702)。

摘　　要：目的观察针刺联合软化冠脉汤对冠心病心绞痛患者的临床疗效及其对血小板聚集率和心率变异性的影响。方法纳入冠心病心绞痛患者104例,随机分为中药组和联合组,每组52例。两组均采用西医常规治疗,中药组口服软化冠脉汤治疗,联合组在中药组治疗基础上加用针刺治疗。比较治疗前后两组患者心绞痛发作情况、中医证候评分;检测两组患者心功能以及肌钙蛋白Ⅰ(cTnⅠ)、超敏肌钙蛋白Ⅰ(hs-TNⅠ)、白细胞介素(IL)-8、IL-17、超敏C反应蛋白(hs-CRP)的水平;比较两组血小板聚集率、心率变异性和临床疗效。结果治疗后,联合组患者心绞痛发作次数、持续时间、中医证候评分均低于中药组(P<0.05);联合组患者心功能指标水平优于中药组(P<0.05);联合组血清cTnⅠ、hs-TNⅠ水平均低于中药组(P<0.05);联合组血清IL-8、IL-17、hs-CRP水平均低于中药组(P<0.05);联合组患者血小板聚集率低于中药组(P<0.05),心率变异性指标水平高于中药组(P<0.05)。联合组治疗后总有效率高于中药组(P<0.05)。结论在西医常规治疗基础上,针刺联合软化冠脉汤治疗可提高冠心病心绞痛的临床疗效,能改善心绞痛发作情况和中医证候,提高患者心功能,减轻心肌损伤严重程度及炎症反应,降低血小板聚集率和心率变异性。Objective To investigate the clinical efficacy of acupuncture plus coronary artery-softening decoction in patients with angina pectoris and its effect on platelet aggregation rate and heart rate variability.Methods One hundred and four patients with angina pectoris were enrolled and randomized to a Chinese herbal medicine group and a combination group,with 52 cases in each group.Both groups received conventional western medical treatment.The Chinese herbal medicine group also received oral administration of coronary artery-softening decoction and the combination group,acupuncture in addition.Angina pectoris episodes and TCM syndrome scores were compared between the two groups of patients before and after treatment.Cardiac function,and cardiac troponin I(cTn I),high-sensitivity troponin I(hs-TN I),interleukin(IL)-8,IL-17 and hypersensitive C-reactive protein(hs-CRP)levels were measured in the two groups of patients.Platelet aggregation rates and heart rate variability and clinical therapeutic effects were compared between the two groups.Results After treatment,the number of angina pectoris episodes was smaller,the duration of angina pectoris was shorter and the TCM syndrome score was lower in the combination group of patients than in the Chinese herbal medicine group(P<0.05).After treatment,cardiac function indicators were better in the combination group of patients than in the Chinese herbal medicine group(P<0.05).After treatment,serum cTn I and hs-TN I levels were lower in the combination group than in the Chinese herbal medicine group(P<0.05).After treatment,serum IL-8,IL-17 and hs-CRP levels were lower in the combination group than in the Chinese herbal medicine group(P<0.05).After treatment,platelet aggregation rate was lower and heart rate variability indicators were higher in the combination group than in the Chinese herbal medicine group(P<0.05).The total efficacy rate was higher in the combination group than in the Chinese herbal medicine group(P<0.05).Conclusions Acupuncture plus coronary artery-softenin

关 键 词：针刺疗法 针药并用 冠状动脉疾病 心绞痛 心率变异性 心功能 

分 类 号：R246.1[医药卫生—针灸推拿学]