改良无痛麦粒化脓灸治疗咳嗽变异性哮喘临床研究  

Clinical Study of Modified Painless Wheat-sized Blistering Moxibustion for Cough Variant Asthma

作　　者：魏忠祥 张庆兰 韩琳[1] 刘颖[1] 苏秀贞[2] 朱海亮 苏全德[2] 张永光[2] WEI Zhong-xiang;ZHANG Qing-lan;HAN Lin;LIU Ying;SU Xiu-zhen;ZHU Hai-liang;SU Quan-de;ZHANG Yong-guang(Shandong University of Traditional Chinese Medicine,Jinan 250000,China;Weifang Hospital of Traditional Chinese Medicine,Weifang 261000,China)

机构地区：[1]山东中医药大学,济南250000 [2]潍坊市中医院,潍坊261000

出　　处：《上海针灸杂志》2021年第6期658-663,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：齐鲁医派中医药特色技术推广项目。

摘　　要：目的观察改良无痛麦粒化脓灸治疗咳嗽变异性哮喘的临床疗效。方法将42例咳嗽变异性哮喘患者随机分为观察组和对照组,每组21例。对照组予布地奈德福莫特罗粉吸入剂吸入治疗,观察组予改良无痛麦粒化脓灸治疗,两组均治疗8周。治疗前、治疗后和治疗后1个月后随访时,观察两组患者中医证候评分的变化。观察治疗前后肺大气道功能指标[第一秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)、呼气流量峰值(PEF)]变化,观察治疗前后肺小气道功能指标[25%、50%、75%肺活量时的最大呼气流速(FEF25%、FEF50%、FEF75%)测定值]的变化。比较两组痊愈患者咳嗽症状消失时间和临床疗效。结果治疗后,两组中医证候评分均较治疗前明显下降(P<0.05),且治疗后组间差异无统计学意义(P>0.05),随访时观察组中医证候评分低于对照组(P<0.05)。治疗后,两组FEV1、FEV1/FVC、PEF均较治疗前明显升高(P<0.05),两组治疗后上述指标组间比较差异无统计学意义(P>0.05)。治疗后,两组FEF25%、FEF50%、FEF75%测定值较治疗前均有提高(P<0.05),两组组间比较差异无统计学意义(P>0.05)。治疗后,观察组12例痊愈患者咳嗽症状消失时间为(6.43±1.47)d,较对照组9例痊愈患者咳嗽症状消失时间短(P<0.05)。治疗后,观察组总有效率高于对照组,组间差异无统计学意义(P>0.05);随访时,观察组痊愈率和总有效率均高于对照组(P<0.05)。结论改良无痛麦粒化脓灸治疗咳嗽变异性哮喘可改善患者咳嗽症状及肺功能,患者咳嗽症状消失时间及远期疗效优于单纯布地奈德福莫特罗粉吸入剂。Objective To observe the clinical efficacy of modified painless wheat-sized blistering moxibustion in treating cough variant asthma(CVA).Method Forty-two CVA patients were randomized into an observation group and a control group,with 21 cases in each group.The control group was intervened by Budesonide and Formoterol fumarate powder for inhalation,while the observation group was given modified painless wheat-sized blistering moxibustion,both for 8 weeks.Before and after treatment and at 1-month follow-up,the changes in traditional Chinese medicine(TCM)symptoms score were observed in the two groups.The pulmonary large airway function indexes[forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FVC)and peak expiratory flow(PEF)],and pulmonary small airway function indexes[forced expiratory flow(FEF)at 25%,50%and 75%of the vital capacity(FEF25%,FEF50%and FEF75%)]were measured before and after treatment.The time taken for cough to relieve in the recovered cases and clinical efficacy were compared between the two groups.Result After treatment,the TCM symptoms score declined significantly in both groups(P<0.05)and there was no significant between-group difference(P>0.05).At follow-up,the TCM symptoms score was lower in the observation group than in the control group(P<0.05).After treatment,FEV1,FEV1/FVC and PEF increased significantly in the two groups(P<0.05),and the between-group differences were statistically insignificant(P>0.05).FEF25%,FEF50%and FEF75%values increased after treatment in both groups(P<0.05),and the between-group differences were statistically insignificant(P>0.05).After treatment,it took(6.43±1.47)d for cough to relieve among 12 recovered cases in the observation group,shorter than that in the control group among 9 recovered cases(P<0.05).After treatment,the total effective rate was higher in the observation group than in the control group,but the difference was statistically insignificant(P>0.05);at follow-up,the recovery rate and total effective rate were higher in the observa

关 键 词：灸法 艾炷灸 直接灸 化脓灸 哮喘 咳嗽 

分 类 号：R246.1[医药卫生—针灸推拿学]