热敏灸联合穴位贴敷治疗肺气亏虚型感染后咳嗽疗效观察  

Observations on the Efficacy of Heat-sensitive Point Moxibustion plus Acupoint Application for Post-infective Cough of Lung-qi Deficiency Type

作　　者：王丽莉[1] 余安胜[1] 吴欢[1] 张平[1] 孙玄厹[1] 陈侃俊 窦丹波[1] WANG Li-li;YU An-sheng;WU Huan;ZHANG Ping;SUN Xuan-qiu;CHEN Kan-jun;DOU Dan-bo(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《上海针灸杂志》2021年第6期664-669,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家自然科学基金项目(81704150);上海市卫健委资助项目(HDC12016242);上海市中医药事业发展3年行动计划(ZYSNXD-YL-CTXK)。

摘　　要：目的观察热敏灸联合穴位贴敷治疗肺气亏虚型感染后咳嗽的临床疗效。方法纳入肺气亏虚型感染后咳嗽患者70例,随机分为治疗组和对照组,每组35例。治疗组予热敏灸联合穴位贴敷治疗,对照组予口服复方甲氧那明胶囊治疗。治疗10 d后观察两组患者的临床疗效及中医证候疗效,比较两组患者治疗前后咳嗽症状评分、中医证候评分及血清白介素(IL)-6、肿瘤坏死因子(TNF)-α水平。结果两组治疗后日间咳嗽评分、夜间咳嗽评分及咳嗽总评分较治疗前均明显降低(P<0.01),且治疗组治疗后均低于对照组(P<0.01,P<0.05)。治疗组治疗后中医证候各项症状评分及总分、IL-6及TNF-α水平较治疗前均显著降低(P<0.01),且均优于对照组(P<0.01,P<0.05)。治疗组临床总有效率及中医证候总有效率分别为88.6%和91.4%,高于对照组的65.7%和17.1%,差异均有统计学意义(P<0.05,P<0.01)。结论热敏灸联合穴位贴敷能显著提高肺气亏虚型感染后咳嗽患者的临床疗效,改善中医证候,降低血清IL-6和TNF-α水平。Objective To investigate the clinical efficacy of heat-sensitive point moxibustion plus acupoint application for post-infective cough of lung-qi deficiency type.Methods Seventy patients with post-infective cough of lung-qi deficiency type were enrolled and randomized to a treatment group and a control group,with 35 cases in each group.The treatment group received heat-sensitive point moxibustion plus acupoint application and the control group,oral administration of compound methoxyphenamine capsules.After 10 days of treatment,the clinical therapeutic effects and the effects on TCM syndrome were evaluated in the two groups of patients,and pre-treatment and post-treatment cough symptom scores,TCM syndrome scores,serum interleukin(IL)-6 and tumor necrosis factor(TNF)-αlevels were compared between the two groups of patients.Results After treatment,the daytime cough score,the nocturnal cough score and the total cough score decreased significantly in two groups compared with before(P<0.05)and were lower in the treatment group than in the control group(P<0.01,P<0.05).After treatment,the TCM syndrome item-symptom scores and total score,and IL-6 and TNF-αlevels decreased significantly in the treatment group compared with before(P<0.01)and were better compared with the control group(P<0.01,P<0.05).The total clinical efficacy rate and the total efficacy rate for TCM syndrome were 88.6%and 91.4%,respectively,in the treatment group,which were higher than 65.7%and 17.1%in the control group,with statistically significant differences(P<0.05,P<0.01).Conclusions Heat-sensitive point moxibustion plus acupoint application can markedly improve clinical therapeutic effect,relieve TCM syndrome and reduce serum IL-6 and TNF-αlevels in patients with post-infective cough of lung-qi deficiency type.

关 键 词：灸法 热敏灸 艾条灸 穴位贴敷 咳嗽 肺气亏虚 肿瘤坏死因子-α 白介素-6 

分 类 号：R246.1[医药卫生—针灸推拿学]