穴位注射对小儿过敏性紫癜疗效、免疫功能及炎性因子的影响  

Efficacy of Acupuncture Point Injection for Children’s Henoch-Schoenlein Purpura and Its Effect on Immune Function and Inflammatory Factors

作　　者：谭春凤 刘建浩[1] 黄文灵 黄建福 TAN Chun-feng;LIU Jian-hao;HUANG Wen-ling;HUANG Jian-fu(Sanya Hospital of Traditional Chinese Medicine,Sanya 572000,China)

机构地区：[1]三亚市中医院,三亚572000

出　　处：《上海针灸杂志》2021年第6期756-761,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：海南省自然科学基金面上项目(817399)。

摘　　要：目的观察在西医常规治疗基础上加用穴位注射对小儿过敏性紫癜患者疗效、免疫功能及炎性因子的影响。方法纳入过敏性紫癜患者108例,采用随机数字表法分为观察组和对照组,每组54例。对照组采用西医常规治疗方法及口服贞芪扶正颗粒治疗,观察组在对照组基础上予穴位注射丹参川芎嗪注射液联合治疗,连续治疗14 d。比较治疗前后两组临床疗效、症状(皮肤紫斑、关节症状、腹痛、便血、发热、咽痛、头痛)评分及消失时间,检测T淋巴细胞亚群(CD3^(﹢)、CD4^(﹢)、CD8^(﹢)、CD4^(﹢)/CD8^(﹢))、免疫球蛋白水平(IgA、IgG、IgM)及血清炎症因子[白介素(IL)-6、IL-10、肿瘤坏死因子(TNF)-α]水平,比较两组临床疗效和复发率。结果观察组显效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后CD3^(﹢)、CD4^(﹢)水平和CD4^(﹢)/CD8^(﹢)明显高于对照组(P<0.05),免疫球蛋白IgA水平低于对照组(P<0.05)。两组治疗后症状评分及血清炎症因子与同组治疗前比较,差异均有统计学意义(P<0.05),且观察组治疗后均优于对照组(P<0.05)。观察组症状消失时间早、复发率低,与对照组比较,差异均有统计学意义(P<0.05)。结论在西药常规治疗基础上,穴位注射可提高小儿过敏性紫癜的疗效,改善患者临床症状,提高患者机体免疫功能,降低血清炎性因子水平,及减少复发率。Objective To investigate the efficacy of acupuncture point injection on the basis of conventional western medical treatment for children’s Henoch-Schoenlein purpura and its effect on immune function and inflammatory factors.Methods One hundred and eight patients with Henoch-Schoenlein purpura were enrolled and allocated,using a random number table,to an observation group and a control group,with 54 cases in each group.The control group received conventional western medical treatment and oral administration of Zhen Qi Fu Zheng granules and the observation group,acupuncture point injection of Salvia miltiorrhiza and Ligustrazine Injectio in addition.Treatments were given for 14 consecutive days.The clinical therapeutic effects,symptom(skin purple spot,joint symptom,abdominalgia,hematochezia,fever,sore throat and headache)scores and times for the symptoms to disappear were compared between the two groups before and after treatment.T lymphocyte subsets(CD3^(﹢),CD4^(﹢),CD8^(﹢) and CD4^(﹢)/CD8^(﹢)),immunoglobulin(IgA,IgG and IgM)levels and serum inflammatory factor[interleukin(IL)-6,IL-10 and tumor necrosis factor(TNF)-α]levels were measured.The clinical therapeutic effects and the recurrence rates were compared between the two groups.Results The marked efficacy rate was higher in the observation group than in the control group with a statistically significant difference(P<0.05).After treatment,CD3^(﹢) and CD4^(﹢) level and CD4^(﹢)/CD8^(﹢) were significantly higher(P<0.05)and IgA levels were lower(P<0.05)in the observation group than in the control group.After treatment,the symptom scores and serum inflammatory factors had statistically significant differences in the two groups compared with before(P<0.05)and were better in the observation group than in the control group(P<0.05).Time for the symptoms to disappear was earlier and the recurrence rate was lower in the observation group than in the control group with statistically significant differences(P<0.05).Conclusions Acupuncture point injection

关 键 词：水针 过敏性紫癜 儿童 免疫功能 炎症因子 

分 类 号：R246.4[医药卫生—针灸推拿学]