Open reading frame 3 protein of hepatitis E virus:Multi-function protein with endless potential  

作　　者：Yong-Lin Yang Yu-Chen Nan 

机构地区：[1]Department of Infectious Diseases,Taizhou People's Hospital,The Fifth Affiliated Hospital of Nantong University,Taizhou 225300,Jiangsu Province,China [2]Department of General Practice,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,Jiangsu Province,China [3]Department of Preventive Veterinary Medicine,Northwest A&F University,Yangling 712100,Shaanxi Province,China

出　　处：《World Journal of Gastroenterology》2021年第20期2458-2473,共16页世界胃肠病学杂志（英文版）

基　　金：National Natural Science Foundation of China,No.31672534;Key Project supported by Medical Science and Technology Development Foundation of Nanjing Department of Health,No.ZKX19026.

摘　　要：Hepatitis E virus (HEV), a fecal-orally transmitted foodborne viral pathogen,causes acute hepatitis in humans and is responsible for hepatitis E outbreaksworldwide. Since the identification of HEV as a zoonotic agent, this virus has beenisolated from a variety of hosts with an ever-expanding host range. HEV-openreading frame (ORF) 3, the smallest ORF in HEV genomes, initially had beenperceived as an unremarkable HEV accessory protein. However, as novel HEVORF3function has been discovered that is related to the existence of a putativethird virion structural form, referred to as “quasi-enveloped” HEV particles, HEVis challenging the conventional virion structure-based classification scheme,which assigns all viruses to two groups, “enveloped” or “non-enveloped”. In thisreview, we systematically describe recent progress that has identified multiplepathogenic roles of HEV-ORF3, including roles in HEV virion release, biogenesisof quasi-enveloped virus, regulation of the host innate immune response, andinterference with host signaling pathways. In addition, implications of HEVORF3-associated quasi-enveloped virions are discussed to guide futuredevelopment of improved vaccines against zoonotic HEV infection.

关 键 词：Hepatitis E virus ZOONOSIS Quasi-enveloped virion Hepatitis E virus-open reading frame 3 Innate immunity 

分 类 号：R373.21[医药卫生—病原生物学]