电针联合穴位埋线治疗慢传输便秘气阴两虚证临床研究  

Clinical Study on Electroacupuncture and Acupoint Embedding for Treatment of Slow Transit Constipation with Qi-yin Deficiency Syndrome

作　　者：杨瑞勇[1] 张桢 王姗姗[2] YANG Ruiyong;ZHANG Zhen;WANG Shanshan(Chongqing Jiangbei District Hospital of Traditional Chinese Medicine,Chongqing 400020,China;Traditional Chinese Medicine Hospital of Chongqing,Chongqing 400021,China)

机构地区：[1]重庆市江北区中医院,重庆400020 [2]重庆市中医院,重庆400021

出　　处：《中国中医药信息杂志》2021年第6期88-93,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：重庆市技术创新与应用发展专项面上项目(setc2019jscx-msxm X0229)。

摘　　要：目的观察电针联合穴位埋线对慢传输便秘气阴两虚证的临床疗效,并探讨其相关机制。方法采用随机数字表法将144例患者分为联合组、电针组和西药组各48例。联合组予电针治疗,1次/d,治疗5 d停2 d;同时进行穴位埋线,1次/2周。电针组仅予电针治疗,方法同联合组。西药组予西沙必利片,10 mg/次,3次/d,口服。3组均连续治疗8周,随访8周。观察3组临床疗效,比较3组治疗前后便秘主要症状评分、便秘患者生存质量自评量表(PAC-QOL)评分、结肠传输试验中标记物排出数及排出率、肠神经递质水平,监测3组不良反应。结果联合组治疗后总有效率为93.75%(45/48),高于电针组的83.33%(40/48)、西药组的75.00%(36/48),差异有统计学意义(P<0.05);联合组随访时总有效率为85.42%(41/48),高于电针组的79.17%(38/48)、西药组的62.50%(30/48),差异有统计学意义(P<0.05)。与本组治疗前比较,3组治疗后、随访时便秘主要症状总分降低(P<0.05);3组治疗不同时点比较,联合组治疗后、随访时便秘主要症状总分均低于电针组、西药组(P<0.05)。与本组治疗前比较,3组治疗后PAC-QOL总分降低(P<0.05);3组治疗后比较,联合组PAC-QOL总分低于电针组、西药组(P<0.05)。与本组治疗前比较,3组治疗后结肠传输试验标记物排出数、排出率升高(P<0.05);3组治疗后比较,联合组标记物排出数、排出率高于电针组及西药组(P<0.05)。与本组治疗前比较,3组治疗后血清血管活性肠肽水平下降,P物质水平升高(P<0.05);3组治疗后比较,联合组血清血管活性肠肽水平低于电针组及西药组(P<0.05),P物质水平高于电针组及西药组(P<0.05)。3组不良反应发生率比较差异无统计学意义(P>0.05)。结论电针联合穴位埋线治疗慢传输便秘气阴两虚证效果满意,可提高患者生存质量,其机制可能是通过调节肠神经递质水平,促进肠蠕动,以减轻便秘症状、减少便秘复发。Objective To observe the clinical efficacy of electroacupuncture combined with acupoint embedding for slow transit constipation with qi-yin deficiency syndrome;To analyze the related mechanism. Methods Totally 144 patients were divided into combination group, electroacupuncture group, and Western medicine group according to random number table method, with 48 cases in each group. The combination group was treated with electroacupuncture, once a day, and a two-day rest followed a five-day treatment;at the same time acupoint embedding was conducted, once two weeks. The electroacupuncture group received only electroacupuncture, and the method was the same as that of the combination group. The Western medicine group was given cisapride tablets, 10 mg/time, 3 times/d, orally. All 3 groups were treated for 8 weeks and followed up for 8 weeks. The clinical efficacy of the three groups were observed. The scores of the main symptoms of constipation, the PAC-QOL scores, the number of markers discharged and the elimination rate in the colonic transit test, and the level of enteric neurotransmitters were compared among the three groups before and after treatment. The adverse reactions of the three groups were monitored. Results The total effective rate after treatment in combination group was 93.75%(45/48), which was higher than 83.33%(40/48) in electroacupuncture group and 75.00%(36/48) in Western medicine group, with statistical significance(P<0.05);the total effective rate at follow-up in combination group was 85.42%(41/48), which was higher than 79.17%(38/48) in electroacupuncture group and 62.50%(30/48) in Western medicine group, with statistical significance(P<0.05). Compared with before treatment, the total scores of main symptoms of constipation in the three groups after treatment and follow-up were reduced(P<0.05). The total scores of main symptoms of constipation after treatment and follow-up in combination group were lower than those in electroacupuncture group and Western medicine group(P<0.05). The total PAC-QOL

关 键 词：电针 穴位埋线 慢传输便秘 肠神经递质 临床研究 

分 类 号：R259.74[医药卫生—中西医结合]