添加剂对断奶仔猪小肠酶活及胃肠道健康的调控作用  

Effects of feed additives on intestinal enzyme activity and gastrointestinal health of weaned piglets

作　　者：樊平[1] 颜邦斌[1] FAN Ping;YAN Bangbin(Nanchong Vocational and Technical College,Nanchong,Sichuan Province 637103,China)

机构地区：[1]南充职业技术学院,四川南充637103

出　　处：《中国饲料》2021年第10期5-8,共4页China Feed

摘　　要：肠道环境在猪的健康中起着至关重要的作用。许多因素,如日粮、微生物群和宿主肠道免疫反应影响肠道环境。碱性磷酸酶是肠道中一种重要的刷状缘酶,可以对细菌脂多糖去磷酸化,从而降低细菌毒性,还可以调节Toll样受体的激活和炎症反应。碱性磷酸酶位于上皮细胞表面的顶端位置,揭示了其在细菌脂多糖解毒中的作用。在断奶仔猪中,碱性磷酸酶的表达下调会增加该阶段仔猪的腹泻率。尽管有些研究报道了碱性磷酸酶在促进肠道健康方面的潜在作用,但关于外源饲料添加剂调节其表达和活性的研究仍是必要的。因此,本综述的主要目的是探讨碱性磷酸酶在仔猪肠道炎症过程中的作用,并探讨一些饲料添加剂对该酶活性的调节及促进仔猪肠道健康的作用。The intestinal environment plays a crucial role in the health of pigs.Many factors,such as diet,microbiota,and host intestinal immune response,influence the intestinal environment.Alkali phosphatase is an important brush border enzyme in the gut,which can dephosphorylate bacterial lipopolysaccharide,thereby reducing bacterial toxicity,and regulating Toll-like receptor activation and inflammatory response.Alkaline phosphatase is located at the top of the surface of epithelial cells,revealing its role in bacterial lipopolysaccharide detoxification.In weaned piglets,the down-regulated expression of alkaline phosphatase increases the diarrhea rate at this stage.Although some studies have reported the potential role of alkaline phosphatase in promoting intestinal health,studies on the regulation of its expression and activity by exogenous feed additives are still needed.Therefore,the main purpose of this review is to investigate the role of alkaline phosphatase in the process of intestinal inflammation in piglets,and to explore the role of some feed additives in regulating the activity of alkaline phosphatase and promoting intestinal health in piglets.

关 键 词：添加剂 断奶仔猪 酶活 胃肠道健康 

分 类 号：S828[农业科学—畜牧学]