Friedel-Crafts:伟大的反应与伟大的合作者  

Friedel-Crafts:The Great Reaction and the Great Collaborators

作　　者：李万方 邓钦月 黄明贤 LI Wan-Fang;DENG Qin-Yue;HUANG Ming-Xian(Department of Chemistry,College of Science,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学理学院化学系,上海200093

出　　处：《化学教育（中英文）》2021年第10期106-111,共6页Chinese Journal of Chemical Education

基　　金：国家自然科学青年基金(21901163)。

摘　　要：傅克反应(Friedel-Crafts Reaction)是迄今为止最古老、应用最长久的碳-碳键形成反应之一,广泛应用于医药、染料、石油等化学工业的各个分支。自1877年被发现以来,傅克反应已经发展成为最经典的有机反应之一,被写进现代有机化学教科书。跟其他重大化学发现类似,傅克反应的发现过程也充满着惊喜和意外,折射出化学家敏锐的洞察力和非同寻常的逻辑推理能力。本文通过整理一些早期的国内外文献和相关化学史料,简述了傅克反应发现的历史背景、发现过程,回顾了两位化学家查理斯·傅列德尔(Charles Friedel)和杰姆斯·克拉夫茨(James Crafts)的一些重要成长经历以及他们接近40年的伟大合作历程。Friedel-Crafts reaction represents one of the oldest and most frequently practiced C-C bond formation reactions,which has been found extensive applications in many chemical industry divisions including medicine,dyes,and petroleum.Since its discovery in 1877,the Friedel-Crafts reaction has been evolved into a classic reaction written into textbooks for organic chemistry.As featured by many other important chemical discoveries,the birth of Friedel-Crafts reaction was also full of serendipities,brimming with keen insights and unexceptional logical reasoning standards from the the chemists.This article briefly summarizes the historical backgrounds related to the discovery of this reaction by reviewing some early literature as well as the upbringing and schooling of Charles Friedel and James Crafts.The nearly 40-years-long cooperation between these two great chemists was also surveyed in retrospect.

关 键 词：傅克反应 化学家 发现 历史 

分 类 号：O6[理学—化学]