HIV-1潜在病毒库的研究进展  

Research advance on the latent reservoir for HIV-1

作　　者：赵胜男 陈晓红[1] ZHAO Shengnan;CHEN Xiaohong(Department of Infectious Diseases,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院感染科,哈尔滨150001

出　　处：《中国艾滋病性病》2021年第5期557-560,共4页Chinese Journal of Aids & STD

基　　金：国家“十三五”科技重大专项(2017ZX10202102-004-001,2018ZX10302104-001-005);黑龙江省自然科学基金(C2017043)。

摘　　要：尽管应用了ART,HIV-1感染的细胞仍然长期存在,这是治疗HIV-1的主要障碍。晚期感染的记忆性CD4细胞是导致病毒持续存在的主要细胞类型,但一些研究表明,非T细胞也可以作为长期的病毒库。目前利用潜伏期反转剂(LRAs)暴露潜伏的HIV-1和通过免疫效应功能杀死暴露细胞的“激活和杀伤”策略得到越来越多人的关注,而艾滋病功能性治愈又逐渐成为目前艾滋病治疗中的研究热点。本文对体内潜伏HIV的细胞、病毒库的持续机制及治疗策略的研究进展进行综述。Reservoirs of HIV-1-infected cells persist long-term despite highly active antiretroviral therapy(ART)and represent the main barrier against a cure for HIV-1.Latently-infected memory CD4 cells are the predominant cell compartments responsible for viral persistence,but some studies suggest that non-T cells can also serve as long-term viral reservoirs.The"shock and kill"strategy aiming to expose latent HIV-1 with latency-reversing agents(LRAs)and kill the exposed cells through immune effector functions is currently attracting more attention.The functional cure of AIDS seems to be a hot spot in the current treatment of AIDS.This paper reviews the recent progress of HIV-1 reservoirs on latent cells in vivo,persistence mechanism,and therapy strategies.

关 键 词：艾滋病病毒 病毒库 治疗策略 

分 类 号：R373.9[医药卫生—病原生物学]