VD在骨骼外系统中的作用及其研究进展  

Research Advances of Functions of Vitamin D in Extra-skeletal System

作　　者：闫鹏辉 张君涛[1] 李娟娟 贺来增 赵英博 张帆[1] 李怡屏 张志平[1] 邓立新[1] YAN Peng-hui;ZHANG Jun-tao;LI Juan-juan;HE Lai-zeng;ZHAO Ying-bo;ZHANG Fan;LI Yi-ping;ZHANG Zhi-ping;DENG Li-xin(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou450000,China)

机构地区：[1]河南农业大学动物医学院,河南郑州450000

出　　处：《畜牧与饲料科学》2021年第3期43-46,共4页Animal Husbandry and Feed Science

基　　金：国家重点研发计划项目“畜禽群发普通病防控技术研究”(2017YFD0502200);农业农村部项目“国家肉牛产业技术体系岗位专家任务肉牛普通病疾病防治岗位”(CARS-37);河南省自然科学基金面上项目“VD3对胎牛肠干细胞Wnt/β-catenin稳态形成机制的研究”(212300410355)

摘　　要：以往普遍认为VD的主要功能是调节Ca离子来促进骨骼的生长和预防佝偻病,但最近几年的研究发现,VD不仅在骨骼疾病中起到重要作用,还与多种骨骼外疾病密切相关,包括一些心血管疾病、代谢紊乱有关的疾病、恶性肿瘤、过敏性疾病、自身免疫性疾病、生殖方面影响等。目前对VD生物学功能的研究比较全面和深入,但大部分是针对人体和小鼠的基础研究,对诸如牛、猪、犬、猫等不同动物VD的骨骼外系统生物学功能的研究较少。在查阅相关文献的基础上,通过对VD在血压、免疫调节、内分泌、子宫内膜和骨骼肌方面的生物学功能和研究进展进行总结,为不同动物VD在骨骼外系统生物学功能的研究提供一定参考。The previous studies demonstrate that the main functions of vitamin D(VD)are to promote bone growth and prevent rickets by regulating Ca ions.However,in recent years,it has been found that VD not only plays an important role in skeletal diseases,but also is closely associated with a variety of extra-skeletal diseases,including cardiovascular diseases,metabolic disorders,malignant tumors,allergic diseases,autoimmune diseases,reproductive diseases,etc.At present,although the researches on the biological functions of VD have become more and more comprehensive and in-depth,most of the them focus on humans and mice.There is limited information on extra-skeletal biological function of VD in different animals,such as cattle,pigs,dogs,cats and so on.Therefore,on the basis of consulting related literatures,this article summarizes the research advances of biological functions of VD on blood pressure,immune regulation,endocrine,endometrial and skeletal muscle,and so on,in hoping to provide a better understanding of biological functions of VD in extra-skeletal system of different animals.

关 键 词：VD 血压 子宫内膜 内分泌疾病 免疫调节 骨骼肌 

分 类 号：Q565[生物学—生物化学]