长链非编码RNA在冠心病发生发展中的作用机制  

The mechanism of long non-coding RNA in the development of coronary heart disease

作　　者：汪羚利 李昭屏[1] 于海奕[1] 高炜[1] Wang Lingli;Li Zhaoping;Yu Haiyi;Gao Wei(Department of Cardiology,Institute of Vascular Medicine,Peking University Third Hospital,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China)

机构地区：[1]北京大学第三医院心内科,血管医学研究所,卫生部心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京100191

出　　处：《中国医学前沿杂志（电子版）》2021年第6期122-127,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家重点研发计划基金(2017YFC0908701)。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)在基因转录、转录后调控、染色体修饰、表观遗传学改变等多个环节方面发挥调控作用,成为包括心血管疾病、肿瘤等疾病的研究热点。lncRNA在冠心病发生、发展过程中的相关机制研究日益丰富,本文对近年来的发现进行总结,为后续深入探索冠心病发病机制和冠心病新的治疗靶点带来启发。Long non-coding RNA(lncRNA)plays an important role in gene transcription,post transcriptional regulation,chromosome modification,epigenetic alterations and so on,which has been a research hotspot in cardiovascular diseases,neoplastic diseases and other diseases.The research of the mechanism of lncRNA in the generation and development of coronary heart disease is increasingly rich.This review summarizes the current research fields,and provides some enlightenment for further study on the pathogenesis and new treatment targets of coronary heart disease.

关 键 词：长链非编码RNA 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]