Meta-Analysis on the associations between Prenatal Perfluoroalkyl Substances Exposure and Adverse Birth Outcomes  

作　　者：LI Fang ZHONG Zhehui XU Chenye ZHANG Beibei MUHAMMAD Aamir SHEN Chensi LIU Shuren YIN Shanshan 李方;钟哲辉;徐晨烨;张贝贝;MUHAMMAD Aamir;沈忱思;刘树仁;尹杉杉(College of Environmental Science and Engineering,Donghua University,Shanghai 201620,China;Water-Energy Resilience Research Laboratory,School of Engineering,Westlake University,Hangzhou 310024,China;College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China;Interdisciplinary Research Academy(IRA),Zhejiang Shuren University,Hangzhou,310015,China)

机构地区：[1]College of Environmental Science and Engineering,Donghua University,Shanghai 201620,China [2]Water-Energy Resilience Research Laboratory,School of Engineering,Westlake University,Hangzhou 310024,China [3]College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China [4]Interdisciplinary Research Academy(IRA),Zhejiang Shuren University,Hangzhou,310015,China

出　　处：《Journal of Donghua University(English Edition)》2021年第2期158-180,共23页东华大学学报（英文版）

基　　金：National Natural Science Foundation of China(No.22006010);Shanghai Sailing Program,China(No.19YF1400500)。

摘　　要：The epidemiological associations between the prenatal perfluoroalkyl substances(PFASs)exposure and the reproductive outcomes remain controversial.A continuous evaluation is needed to combine the inconsistent results.In this study,we explored the associations between PFASs exposure and the low birth weight(LBW),preterm birth and small for gestational age(SGA).The quality of selected literature,quantitative estimates,publication bias and subgroup analysis were performed on the basis of 17 retrieved articles published before December 2020.The results showed a significant positive association between the perfluorooctane sulfonate(PFOS)exposure and the risk of LBW[Odds ratio(OR)=1.17;95%confidence interval(CI):1.01,1.36;heterogeneity:P=0.30,I2=17%].The positive association was also observed between the PFOS and the risk of preterm birth(OR=1.19;95%CI:1.01,1.39,P=0.007;I2=62%).There was a paucity of evidence regarding the negative effects of perfluorooctanoic acid(PFOA),perfluorohexanesulfonic acid(PFHxS)and perfluorononanoic acid(PFNA)on the pregnancy outcomes.The findings from the subgroup analysis(the sampling period,the birth gender and biologic specimens)did not substantially altered the results of the overall pooled estimate ORs.The increased prevalence of negative birth outcomes with gestational PFASs exposure warrants further explorations from biological process perspective.

关 键 词：perfluoroalkyl substances(PFASs) META-ANALYSIS low birth weight(LBW) small for gestational age(SGA) preterm birth 

分 类 号：X82[环境科学与工程—环境工程] R18[医药卫生—流行病学]