咸阳市2016-2019年手足口病病原学检测分析  

Etiology and Characteristics of Hand,Foot and Mouth Disease in Xianyang City,China,2016–2019

作　　者：陈斌 张俊君 秦龙 王士峰 郭祎阁 CHEN Bin;ZHANG Junjun;QIN Long;WANG Shifeng;GUO Yig(Shaanzi Provincial Center for Disease Control and Prevention,Xi'an 710054,China;Xianyang City Center for Disease Control and Prevention,Xianyang 712000,China;College of Geology and Environment,Ki'an Unitversitly of Science and Technology,Xi'an 710054,China)

机构地区：[1]陕西省疾病预防控制中心,西安710054 [2]咸阳市疾病预防控制中心,西安712000 [3]西安科技大学地质与环境学院,西安710054

出　　处：《病毒学报》2021年第3期633-637,共5页Chinese Journal of Virology

摘　　要：本文通过对咸阳市2016-2019年手足口病(Hand,foot and mouth disease,HFMD)病原检测结果进行分析,阐明了咸阳市近四年HFMD病原谱的构成和流行特征,为HFMD防控工作提供依据。对2016-2019年收集的2 711例HFMD病例标本进行荧光定量PCR检测确定肠道病毒型别,构建咸阳市HFMD病原谱并对阳性病例的流行特征进行描述性分析。2 711例HFMD病例实验室确诊1 444例(阳性率为53.26%),其中肠道病毒A组71型(Enterovirus 71,EV71)占病原谱构成的12.74%、柯萨奇病毒A组16型(Coxsackievirus A16,CoxA16)占27.49%、柯萨奇病毒A组10型(Coxsackievirus A10,CoxA10)占5.19%、柯萨奇病毒A组6型(Coxsackievirus A6,CoxA6)占43.21%、其他肠道病毒(Enterovirus,EV)占11.36%。CoxA6和CoxA16交替居于咸阳市HFMD病原谱首位。咸阳市HFMD流行具有明显季节性和地区差异以及特定人群高发,夏季(5~7月)为发病主高峰,秋冬季(10~11月)为次高峰,主要集中在人口较多的市区,4岁以下散居儿童为易感人群,且男性发病率高于女性。今后的防控工作中应继续加强咸阳市HFMD监测,重视其他EV的监测工作,实时监测HFMD病原谱的变化。在高发季节,针对高发人群,采取积极有效干预措施,加强防控工作。We wished to clarify the composition and epidemic characteristics of hand,foot and mouth disease(HFMD)in Xianyang City,China,in 2016 – 2019 through pathogen detection. In this way,we wished to provide a basis for the prevention and control of HFMD. The samples of 2711 HFMD cases collected from 2016 to 2019 were detected by fluorescence quantitative polymerase chain reaction to determine the enterovirus(EV)type. The pathogen spectrum of HFMD in Xianyang City was constructed,and the epidemiologic characteristics of positive cases were evaluated descriptively. Among the 2711 cases of HFMD,1444 cases were laboratoryconfirmed(positive rate was 53.26%),of which enterovirus group A type 71(EV71)accounted for 12.74%,coxsackievirus group A type 16(CoxA16)accounted for 27.49%,coxsackievirus group A type 10(CoxA10)accounted for 5.19%,coxsackievirus group A type 6(CoxA6) accounted for 43.21%,and other EVs accounted for 11.36%. CoxA6 and CoxA16 formed major parts of the HFMD pathogen spectrum in Xianyang City. HFMD prevalence in Xianyang City had obvious seasonal and regional differences as well as a high prevalence in specific age groups. The main peak of HFMD was in summer(May to July)and the secondary peak was in autumn and winter(October to November). HFMD was concentrated mainly in urban areas with large population. In future prevention-and-control projects,we should continue to strengthen HFMD monitoring in Xianyang City,pay more attention to other EVs,and measure changes in the HFMD pathogen spectrum in real time. In the peak seasons of HFMD,active and effective intervention measures should be undertaken to strengthen prevention and control of HFMD.

关 键 词：手足口病(HFMD) 肠道病毒(EV) 病原学 流行病学 

分 类 号：R373.2[医药卫生—病原生物学] R181.1[医药卫生—基础医学]