人肠道病毒71型基因重组的研究进展  

Research Progress in Gene Recombination of Human Enterovirus A71

作　　者：张海陆 宋绍霞[2] 温红玲 ZHANG Hailu;SONG Shaoxia;WEN Hongling(Department of Microbiological Laboratory Technology School of Public Health,Shandong University,Jinan 250012,China,Keylaboratory for the Prervention and Control of lnfectious Diseases;Shandong Center for Disease Control and Prevention,Jinan 250012,China,Shandong Provincial Key Laboratory of Iwfectious Disease Prevention and Control)

机构地区：[1]山东大学公共卫生学院微生物检验学系感染性疾病防控重点实验室,济南250012 [2]山东省疾病预防控制中心山东省传染病预防控制重点实验室,济南250012

出　　处：《病毒学报》2021年第3期758-763,共6页Chinese Journal of Virology

基　　金：山东省自然科学基金面上项目(ZR2018MH035);山东省重点研发计划(2019GSF107067)。

摘　　要：人肠道病毒71型(Enterovirus 71,HEV-A71),是手足口病(Hand,foot and mouth disease,HFMD)的常见病因,属于人肠道病毒属中的肠道病毒A型,隶属于微小RNA病毒科。许多研究证明HEV-A71经常发生基因重组并且使得HEV-A71在全球内多次暴发,这对疫苗的研发和疾病的防控是一种新的挑战。本文对HEV-A71不同亚型内、不同型间和多重重组等不同基因重组类型及其毒力、抗原性变化进行了综述。Human enterovirus A71(HEV-A71)is a common cause of hand,foot and mouth disease(HFMD).It belongs to human enterovirus species A in genus Enterovirus within the family Picornaviridae.Several studies have shown that genetic recombination is important and often occurs in HEV-A71,and HEV-A71 outbreaks have occurred several times worldwide.This phenomenon brings new challenges to vaccine development and prevention/control of HFMD.Here,we review the different genetic recombination types,virulence and antigenic changes of HEV-A71.

关 键 词：人肠道病毒71型 基因重组 疫苗 毒力 抗原性 

分 类 号：R373.2[医药卫生—病原生物学]