甲基化修饰对病毒潜伏感染的调控作用研究进展  

Research Advances in the Role of Methylation in Latent Viral Infections

作　　者：孙微微 贾怀杰[2] 景志忠[2] 陈思睿 吕彦蓉 刘荣 王晓霞 SUN Weiwei;JIA Huaijie;JING Zhizhong;CHEN Sirui;LYU anrong;LIU Rong;WANG Xiaoxia(School of Publc Health,Lanzhou Untoersity,Lanzhou 73000,China;State Key Laboratory of Veterinary Etological Biology,KeyLaboratory of Veterinary Public Health of Ministry of Agriculture,Lanzhou Veterinary Reearch Institute,Chinese Academy of Agricultaral Sciences,Lanzhou 730000,China)

机构地区：[1]兰州大学公共卫生学院,兰州730000 [2]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部兽医公共卫生重点实验室,兰州730000

出　　处：《病毒学报》2021年第3期764-770,共7页Chinese Journal of Virology

基　　金：国家自然基金项目(项目号:81501734),题目:APOBEC3对潜伏HIV-1的激活作用及其与DNA甲基化修饰的关系;甘肃省自然基金项目(项目号:20JR5RA215),题目:干扰素诱导蛋白IFITs在羊口疮病毒感染中的作用及其与病毒2’-O-甲基化修饰的关系研究。

摘　　要：病毒在宿主体内所建立的潜伏感染与肿瘤、免疫性疾病等多种疾病的发生和发展密切相关,并直接导致相关疾病很难被彻底治愈。目前,随着潜伏感染调控机制研究的深入,表观遗传修饰在其中扮演的角色也进一步被发现。而甲基化作为其中最重要,也是研究最详尽的调控方式之一,在病毒潜伏感染的建立和维持中也是不可或缺的。本文将分别对DNA、RNA和组蛋白甲基化在病毒潜伏感染中的调控作用、靶向甲基化修饰的药物在临床治疗中的应用前景等方面进行综述,以期为抗病毒治疗策略的研究提供参考。A latent viral infection(LVI) established in a host is closely related to the occurrence and development of various diseases(e.g.,cancer,immunologic diseases). It also hampers complete cure of related diseases. With increased research on LVI mechanisms,the part played by epigenetic modifications has been elucidated. Methylation,as one of the most important and well-studied modifications,is also indispensable in the establishment and maintenance of LVIs. This review summarizes the regulatory role of DNA,RNA,and histone methylation in LVIs. We also discuss the prospect of candidate drugs targeting methylation modification,which could provide basic knowledge for the study of antiviral-therapy strategies.

关 键 词：甲基化修饰 病毒潜伏感染 抗病毒治疗 

分 类 号：R373.9[医药卫生—病原生物学]