干细胞治疗海绵体神经损伤性勃起功能障碍的临床研究进展  

Clinical research progress of stem cells in the treatment of erectile dysfunction caused by cavernous nerve injury

作　　者：王坚 黄嘉豪 石天昊 黄文杰 吕伯东 WANG Jian;HUANG Jiahao;SHI Tianhao;HUANG Wenjie;LYU Bodong(The Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China;Department of Urology,the Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,Zhejiang,China;Department of Urology,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江中医药大学附属第二医院泌尿外科,杭州310005 [3]浙江大学医学院附属第二医院泌尿外科,杭州310000

出　　处：《中国性科学》2021年第5期1-4,共4页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金面上项目(82074433);国家临床重点专科项目(ZJ1101WK023);浙江省自然科学基金(LY18H050004)。

摘　　要：勃起功能障碍(ED)是指阴茎勃起程度无法实现和(或)难以维持足以令人满意的性生活。海绵体神经损伤(CNI)是ED的常见原因,但目前临床上的一二线ED疗法对CNI所致ED的疗效并不理想。干细胞以其具有自我更新、多向分化和无限增殖等特点被广泛用于治疗神经损伤的研究。随着干细胞治疗技术的快速发展,使之应用于ED的治疗成为可能。本综述围绕不同干细胞的特点及其作用机制,探讨干细胞治疗CNI性ED的基础及临床研究现状,总结干细胞治疗的有效性、优势性及安全性等相关问题。Erectile dysfunction(ED) is a sexual disorder defined as the inability to initiate or maintain an erection that is satisfactory for sexual intercourse. Cavernous nerve injury(CNI) is a common cause of ED, but the curative effect of first-line and second-line therapy on ED caused by CNI is not ideal. Stem cells are widely used to treat nerve injury because of their self-renewal, multi-directional differentiation and unlimited proliferation. With the rapid development of stem cell therapy technology, it is possible to apply it to the treatment of ED. This review will focus on the characteristics and mechanisms of different stem cells, explore the basic and clinical research status of stem cells in the treatment of CNI ED, and summarize the effectiveness, advantages and safety of stem cell therapy.

关 键 词：干细胞 海绵体神经损伤 勃起功能障碍 

分 类 号：R698[医药卫生—泌尿科学]