45例艾滋病合并马尔尼菲青霉病临床特征分析  

Clinical characteristics of 45 cases of AIDS with penicilliosis marneffei

作　　者：周昌静[1] 黄卫娥 余小舒 ZHOU Changjing;HUANG Wei′e;YU Xiaoshu(Department of Infectious Diseases,Baise People′s Hospital,Baise 533000,Guangxi,China)

机构地区：[1]百色市人民医院感染性疾病科,广西百色533000

出　　处：《中国性科学》2021年第5期140-142,共3页Chinese Journal of Human Sexuality

基　　金：百色市科学研究与技术开发计划(百科20184204)。

摘　　要：目的探讨艾滋病(AIDS)合并马尔尼菲青霉病(PSM)患者的临床特征。方法采取整群抽样方法选取2018年10月至2020年1月百色市人民医院住院治疗并经病原学确诊为AIDS合并PSM的45例患者作为研究对象。回顾性分析其临床资料,总结其临床特点。结果临床表现主要为发热、消瘦、皮疹、咳嗽、气促、腹痛、肝脾肿大、淋巴结肿大,多重感染现象常见,肺部感染32例(71.11%);其余为口腔念珠菌病9例(20.00%),霉菌性食管炎1例(2.22%),慢性乙肝5例(11.11%),败血症1例(2.22%)。肝硬化1例(2.22%),消化道出血2例(4.44%)。结论 PSM可累及多个器官,临床症状表现各异。对CD4+细胞在50个/mL以下,发热、消瘦、皮疹、肝脾肿大、浅表淋巴结肿大的AIDS患者,建议考虑马尔尼菲青霉菌(PM)感染,采取不同标本培养鉴定,以早确诊、早治疗,降低患者病死率。Objective To explore the clinical characteristics of acquired immune deficiency syndrome(AIDS) patients with penicilliosis marneffei(PSM). Methods 45 patients with AIDS complicated with PSM who were hospitalized in Baise People′s Hospital from October 2018 to January 2020 and confirmed by etiology were enrolled as the research subjects by cluster sampling method, to summarize the clinical characteristics by retrospectively analyze the clinical data. Results The main clinical manifestations were fever, emaciation, rash, cough, shortness of breath, abdominal pain, hepatosplenomegaly and lymph node enlargement. Multiple infections were common, including32 cases of lung infection(71.11%), 9 cases of oral candidiasis(20.00%), 1 case of mycotic esophagitis(2.22%), 5 cases of chronic hepatitis B(11.11%), 1 case of sepsis(2.22%), 1 case of liver cirrhosis(2.22%) and 2 cases ofgastrointestinal bleeding(4.44%). Conclusions PSM can involve multiple organs with different clinical manifestations. For AIDS patients with CD4+ cells less than 50/mL, fever, emaciation, skin rash, hepatosplenomegaly and superficial lymph node enlargement, it is recommended to consider penicillium marneffei(PM) infection, adopt different specimen culture to identify, so as to make early diagnosis and early treatment, and reduce the mortality rate of patients.

关 键 词：艾滋病 马尔尼菲青霉病 临床特征 

分 类 号：R759[医药卫生—皮肤病学与性病学]