外周血CD4细胞中调节性T细胞占比与尿道口和(或)肛周尖锐湿疣复发的关系  

Relationship between the ratio of Treg to CD4 cells in peripheral blood and recurrence of condyloma acuminatum in urethral orifice and perianal region

作　　者：付伟 郭娇燕 邱盼盼 FU Wei;GUO Jiaoyan;QIU Panpan(Department of Dermatology,Zaozhuang Dermatology and Venereal Disease Prevention and Treatment Hospital,Tengxhou 277599,Shandong,China)

机构地区：[1]枣庄市皮肤病性病防治院皮肤科,山东滕州277599

出　　处：《中国性科学》2021年第5期143-145,共3页Chinese Journal of Human Sexuality

摘　　要：目的研究外周血CD4细胞中调节性T细胞(Treg)占比(简称Treg占比)与尿道口和(或)肛周尖锐湿疣(CA)复发的关系。方法采用便利抽样法选取2019年1月至2020年1月枣庄市皮肤病性病防治院诊治的124例(初发68例,复发56例)尿道口和(或)肛周CA患者纳入观察组,同期选取120例健康体检者纳入对照组。观察组接受5-氨基酮戊酸(ALA)-光动力疗法(PDT),1次/周,治疗3次。比较两组外周血Treg占比,并分析CA初发和复发患者治疗前后外周血Treg占比变化情况。结果观察组治疗前外周血Treg占比显著高于对照组(P<0.05)。CA初发和复发患者3次治疗后外周血Treg占比均低于治疗前,第2、3次治疗后显著低于第1次治疗后,第3次治疗后显著低于第2次治疗后,差异具有统计学意义(P<0.05);复发患者治疗前后外周血Treg占比均高于初发患者,差异具有统计学意义(P<0.05)。结论外周血Treg占比偏高会增加尿道口和(或)肛周CA复发风险,而多次ALA-PDT治疗可能通过改变皮疹状态下调外周血Treg占比,故临床应建议患者在条件允许时于疣体全部消退后适当行低剂量ALA-PDT维持治疗或其他对症治疗。Objective To study the relationship between the ratio of regulatory T cells(Treg) to peripheral blood CD4 cells and recurrence of condyloma acuminatum(CA) in urethral orifice and/or perianal region. Methods 124 patients(68 cases of initial onset and 56 cases of recurrence) with CA around urethral orifice and/or anus diagnosed and treated in Zaozhuang Dermatology and Venereal Disease Prevention and Treatment Hospital from January 2019 to January 2020 were selected as the observation group by convenience sampling method, and 120 healthy subjects during the same period were selected as the control group. Observation group received 5-aminogketo-valeric acid(ALA)-photodynamic therapy(PDT) once a week, 3 times. The proportion of Treg in peripheral blood was compared between the two groups, and the changes in the proportion of Treg in peripheral blood before and after treatment in patients with initial and recurrent CA were analyzed. Results The proportions of Treg in peripheral blood after the third treatment were all lower than those before treatment, after the second and third treatment were significantly lower than those after the first treatment, and after the third treatment was significantly lower than that after the second treatment, with statistical significance(P<0.05). The proportion of Treg in peripheral blood of recurrent patients before and after treatment was higher than that of initial diagnosed patients(P<0.05). Conclusions The high proportion of Treg in peripheral blood will increase the risk of recurrence of CA in urethral orifice and/or perianal area. Multiple ALA-PDT treatment may reduce the proportion of Treg in peripheral blood by changing the rash state. Therefore, it is suggested that patients should be given low-dose ALA-PDT maintenance treatment or other symptomatic treatment after the warts are completely subside when conditions permit.

关 键 词：调节性T细胞 尖锐湿疣 5-氨基酮戊酸-光动力疗法 复发 

分 类 号：R759[医药卫生—皮肤病学与性病学]