TG/HDL-C比值与血液透析患者全因死亡的相关性研究  

Correlation between TG/HDL-C Ratio and All-cause Death in Hemodialysis Patients

作　　者：董云萍 蒋红樱[1] 李玉凤[1] 李晶[1] 张春秀 Dong Yunping;Jiang Hongying;LI Yufeng(The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院,650101

出　　处：《医学研究杂志》2021年第5期125-129,共5页Journal of Medical Research

基　　金：昆明医科大学研究生创新基金资助项目(2020S189)。

摘　　要：目的探讨甘油三脂/高密度脂蛋白胆固醇(TG/HDL-C)比值与血液透析(hemodialysis,HD)患者病死率之间的关系。方法本研究纳入2014年6月1日~2015年5月31日于昆明医科大学第二附属医院肾脏内科进行HD治疗达3个月及以上的195例患者为研究对象,进行为期4年的随访。TG/HDL-C比值根据三分位分为N1组(TG/HDL-C≤0.99),N2组(TG/HDL-C:1.00~1.74)和N3组(TG/HDL-C>1.74),采用Kaplan-Meier生存曲线比较3组患者的生存率,利用COX回归分析HD患者全因死亡及心血管事件(CVD)死亡的影响因素。结果Kaplan-Meier生存曲线显示,N3组患者的生存率显著高于N1组、N2组患者(P<0.05)。COX比例风险回归模型分析显示,以N1组为参照,N3组是HD患者全因死亡(HR=0.226,95%CI:0.086~0.595,P=0.003)的保护因素,而与CVD死亡无明显相关(HR=0.405,95%CI:0.115~1.426,P=0.159)。结论高TG/HDL-C比值是血液透析患者全因死亡的独立保护因素,而与心血管事件死亡无明显相关。Objective To investigate the relationship between the hemodialysis(HD)mortality and the hemodialysis ratio of triglycerides/HDL-C.Methods In this study,195 patients who received HD treatment in the second affiliated nephrology department of kunming medical university for 3 months or more on May 31,2015 were included in 1 solstice in June 2014 and followed up for 4 years.The TG/HDL-C ratio was divided into N1 group(TG/TG/HDL-C≤0.99),N2 group(TG/HDL-C:1.00-1.74)and N3 group(TG/HDL-C>1.74)according to the trimester.Kaplan-meier survival curve was used to compare the survival rate of patients in the three groups.COX regression model was used to analyze the risk factors of all-cause death and cardiovascular event(CVD)death in HD patients.Results Kaplan-Meier survival curve showed that the survival rate of patients in group N3 was significantly higher than that of patients in group N1 and N2(P<0.05).COX proportional hazard regression model analysis showed that,taking N1 group as the reference,N3 group was a protective factor for all-cause death(HR=0.226,95%CI:0.086-0.595,P=0.003)in HD patients,but was not associated with DEATH from CVD(HR=0.405,95%CI:0.115-1.426,P=0.159).Conclusion High TG/HDL-C ratio is an independent protective factor for all causes of death in hemodialysis patients,but has no significant correlation with cardiovascular event death.

关 键 词：血液透析 TG/HDL-C比值 病死率 

分 类 号：R692.5[医药卫生—泌尿科学]