复方丹参滴丸与麝香保心丸分别治疗不稳定型心绞痛的药物经济学评价  

Pharmacoeconomic Evaluation of Compound Danshen Dropping Pills and Shexiang Baoxin Pills in the Treatment of Unstable Angina Pectoris

作　　者：李雪靖[1] 王宪英[1] 郄素会[1] 韩丽[1] LI Xuejing;WANG Xianying;QIE Suhui;HAN Li(Dept.of Pharmacy,the Third Hospital of Hebei Medical University,Hebei Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院药剂科,河北石家庄050051

出　　处：《中国医院用药评价与分析》2021年第5期584-589,共6页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局科研计划项目(No.2018130)。

摘　　要：目的:综合评价复方丹参滴丸与麝香保心丸对比治疗不稳定型心绞痛(unstable angina pectoris,UAP)的临床效果和经济性。方法:全面检索中国知网、万方数据库、维普数据库和Pubmed等4个数据库,纳入在常规治疗基础上使用复方丹参滴丸或麝香保心丸治疗UAP的随机对照试验。通过贝叶斯网状Meta分析,比较两种药物的治疗效果,根据Meta分析结果选择成本-效果分析法或最小成本分析法来比较两者的经济性。结果:共纳入53篇文献,包含8460例UAP患者。Meta分析结果显示,复方丹参滴丸与麝香保心丸治疗UAP的临床有效率比较,差异无统计学意义(RR=0.96,95%CI=0.87~1.07,P>0.05)。最小成本分析结果显示,复方丹参滴丸、麝香保心丸的治疗费用分别为121.7、191.5元;敏感性分析结果证明了该结果的稳健性。结论,在治疗UAP方面,复方丹参滴丸的经济性优于麝香保心丸。由于纳入研究质量一般,该结论有待大样本、高质量的临床随机对照试验进一步验证。OBJECTIVE:To comprehensively evaluate the clinical effect and economy of compound Danshen dropping pills and Shexiang baoxin pills in the treatment of unstable angina pectoris(UAP).METHODS:CNKI,Wanfang database,VIP database and PubMed were retrieved to collect the randomized controlled trial of compound Danshen dropping pills or Shexiang baoxin pills in the treatment of UAP on the basis of conventional treatment.Bayesian network Meta analysis was performed to compare the clinical effect of two regimens.According to the results of Meta analysis,cost-effectiveness analysis or minimum-cost analysis were selected to compare the economics of two regimens.RESULTS:A total of 53 literature were included,including 8460 patients with UAP.Meta analysis showed that there was no statistically significant difference in the clinical effectiveness of compound Danshen dropping pills and Shexiang baoxin pills in the treatment of UAP(RR=0.96,95%CI=0.87-1.07,P>0.05).Minimum cost analysis showed that the treatment cost of compound Danshen dropping pills and Shexiang baoxin pills were respectively 121.7 yuan and 191.5 yuan.The results of sensitivity analysis proved the robustness of the results.CONCLUSIONS:In the treatment of UAP,compound Danshen dripping pills are more economical than Shexiang baoxin pills.Due to the general quality of the study,this conclusion needs to be further verified by large sample,high-quality randomized controlled clinical trials.

关 键 词：复方丹参滴丸 麝香保心丸 不稳定型心绞痛 药物经济学评价 

分 类 号：R932[医药卫生—生药学]