调整优化采血联袋后制备浓缩血小板的质量分析  

Quality analysis of platelet concentrates prepared with optimized blood collection bags

作　　者：肖达玲 杨坤 韦家寿 黄新宝 林国奎 陶珏宇 何永红 XIAO Daling;YANG Kun;WEI Jiashou;HUANG Xinbao;LIN Guokui;TAO Jueyu;HE Yonghong(Guigang Central Blood Station,Guigang 537100,China)

机构地区：[1]贵港市中心血站,广西贵港537100

出　　处：《中国输血杂志》2021年第5期535-537,共3页Chinese Journal of Blood Transfusion

基　　金：广西壮族自治区医药卫生科技项目《同一全血制备去白悬浮红细胞浓缩血小板冷沉淀血浆等四种成分的应用研究》(Z20200693)。

摘　　要：目的对两种不同采血联袋制备浓缩血小板的质量进行评价,为高质量制备血小板的开展提供参考依据。方法采用白膜法分别对原一次性使用去白细胞采输血器和调整优化后的一次性使用去白细胞采输血器所采集的全血制备浓缩血小板,全血采集量为400 mL,共60袋。分两组,A组(一次性使用去白细胞采输血器原袋)30袋,白膜成分袋尺寸为15×12 cm;B组(一次性使用去白细胞采输血器调整袋)30袋,白膜成分袋尺寸为11×9 cm。结果比较红细胞混入量、血小板含量、血小板回收率指标,2组红细胞混入量、血小板含量、血小板回收率3项比较,差异有统计学意义(P<0.05),A组红细胞混入量、血小板含量、血小板回收率分别为(2.62±0.57)×10^(9)/mL、(4.41±0.31)×10^(10)/mL、(55.03±0.06)%,B组红细胞混入量、血小板含量、血小板回收率分别为(1.37±0.35)×10^(9)/mL、(6.21±0.63)×10^(10)/mL、(79.23±0.09)%。结论优化尺寸为11×9 cm的白膜成分袋制备的浓缩血小板质量更优,更好地提高临床输血的安全性及有效性。Objective To evaluate the quality of platelet concentrates prepared by two different blood collection bags, so as to provide references for the development of high-quality platelet preparation.Methods Platelet concentrates were prepared using buffy coating from the whole blood collected by conventional and optimized single-use blood collection bags with leukoreduction filter, respectively. The volume of whole blood collected was 400 mL,and 60 bags in total. They were divided into group A(conventional collection bags, n=30), and the size of buffy coating pouch was 15 cm×12 cm;group B(optimized collection bags, n=30), and the size of buffy coating pouch was 11 cm×9 cm. Results There were significant differences between group A and group B in the amount of red blood cells contamination, platelet content, and platelet yielding rate(P<0.05), which were(2.62±0.57)×10^(9)/mL vs(1.37±0.35)×10^(9)/mL,(4.41±0.31)×10^(10)/mL vs(6.21±0.63)×10^(10)/mL, and(55.03±0.06)% vs(79.23±0.09)%, respectively. Conclusion The buffy coating pouch with the size of 11 cm×9 cm can produce better platelet concentrates, thus improves the safety and efficacy of clinical blood transfusion.

关 键 词：采血联袋 血小板质量 输血安全 调整优化 

分 类 号：R331.143[医药卫生—人体生理学] R457.12[医药卫生—基础医学]