自体输血在妇科肿瘤患者手术中的应用分析  

Analysis of the Application of Autotransfusion in the Operation of Gynecological Tumor Patients

作　　者：覃予思 李元波 薛颖泓 姜衡春[1] 郑泽斌 陈铃[1] QIN Yu-si;LI Yuan-bo;XUE Ying-hong(Department of Blood Transfusion,Guangxi Medical University Cancer Hospital,Nanning,Guangxi 530021)

机构地区：[1]广西医科大学附属肿瘤医院输血科,广西南宁530021

出　　处：《临床输血与检验》2021年第3期314-318,共5页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：广西自然科学基金(No.2019GXNSFDA245001)资助。

摘　　要：目的探讨自体输血在妇科肿瘤患者手术中的应用及效果。方法对432例手术的妇科肿瘤患者输血情况进行回顾性分析,其中分别选取宫颈癌和卵巢肿瘤患者,并分为观察组(输注自体血)和对照组(输注异体血),对比两组免疫和血液学指标变化情况。结果①432例手术患者术后诊断中,宫颈癌占40%,卵巢肿瘤占30%,其它妇科肿瘤占30%,用血量1325.5 U。其中199例术前采集自体血295U,自体输血率22.26%。②宫颈癌患者免疫方面观察组术后IgG明显降低(P<0.05);组间对比,对照组CD4^(+)/CD8^(+)降低更显著(P<0.05)。血液学方面观察组术后TT明显延长(P<0.05)。③卵巢肿瘤患者观察组IgM、IgG、IgA明显降低(P<0.05)。结论两种输血方法在短期内对妇科肿瘤患者免疫和血液功能的影响无显著差异,且回输自体血的患者不会因采血后循环血容量减少而导致指标异常。Objective To explore the application and effect of autotransfusion in patients with gynecological tumor surgery.Methods A retrospective analysis of blood transfusion in 432 gynecological tumor patients undergoing surgery was conducted.Patients with cervical cancer and ovarian tumor were selected and divided into observation group(autologous blood transfusion)and control group(allogeneic blood transfusion).The changes of immunological and hematological indexes were compared between the two groups.Results①Among the 432 patients diagnosed after operation,cervical cancer accounted for 40%,ovarian tumors accounted for 30%,other gynecological tumors accounted for 30%,and the blood consumption was 1325.5 U.In 199 cases,295 U of autologous blood was collected preoperatively,and the rate of autologous blood transfusion was 22.26%.②In the aspect of immunity,IgG in observation group was significantly decreased after operation in patients with cervical cancer(P<0.05).Comparison between groups,CD4^(+)/CD8^(+)ratio of T lymphocytesdecreased significantly in control group(P<0.05).In hematology,TT was significantly prolonged in the observation group(P<0.05).③In ovarian tumor patients,IgM,IgG and IgA in observation group were significantly decreased(P<0.05).Conclusion There was no significant difference in the effect of the two transfusion methods on the immunological and hematological function of gynecological tumor patients in the short term.The indexes of patients with autologous blood transfusion would not be abnormal due to the decrease of circulating blood volume after blood collection.

关 键 词：恶性肿瘤 自体输血 异体输血 择期手术 输血效果 

分 类 号：R457.1[医药卫生—治疗学]