药物包被红细胞法和药物添加法检测358例贫血患者抗生素类药物性抗体结果分析  

Characteristics of Antibiotic-Induced Red Blood Cell Antibodies in 358 Patients with Anemia

作　　者：陈凤 郑洋洋 CHEN Feng;ZHENG Yang-yang(Baotou Medical College,Baotou 014010)

机构地区：[1]内蒙古自治区人民医院临床输血科,014010 [2]包头医学院

出　　处：《临床输血与检验》2021年第3期327-332,共6页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：内蒙古自治区人民医院院内基金项目(No.2020YN16)资助。

摘　　要：目的分析某医院使用抗生素后出现贫血的患者药物性抗体发生频率,并结合相关临床资料进行综合分析保障输血安全。方法选取某医院临床应用抗生素类药物≥3天后出现贫血的住院患者血标本358例,应用药物包被的红细胞法和药物添加法两种方法进行抗生素类药物性抗体的检测,并查阅患者相关临床资料对实验结果进行综合分析。结果在358例贫血患者血标本中,应用药物包被的红细胞法共检测出抗生素类药物性抗体阳性12例,358例贫血患者的阳性率为3.35%。其中头孢类药物性抗体共检测284例,阳性6例,阳性率为2.11%,非头孢类药物性抗体共检测74例,阳性6例,阳性率为8.11%,头孢类药物性抗体与非头孢类药物抗体阳性率比较,差异有统计学意义(P<0.05);12例抗生素类药物性抗体阳性患者,分别按性别、年龄、是否手术统计比较,差异均无统计学意义(P>0.05);应用药物添加法所有患者血标本均未检测到抗生素类药物性抗体。结论两种方法对抗生素类药物性抗体检出率有所不同,其中药物包被红细胞法阳性率明显高于药物添加法。输血科医师及临床医师应对抗生素类药物性抗体的不良影响应给予重视。Objective The drug-coated red blood cells(RBCs)method and the drug-addition method were used for detecting the incidence of drug-induced antibodies in patients developed anemia after antibiotics treatment and comprehensively analyzed related clinical data.Method We selected 358 blood samples from hospitalized patients developed anemia after antibiotics treatment for 3 days or more in a hospital.The drug-coated RBCs method and the drug-addition method were used to detect drug-induced antibodies.We comprehensively analyzed the test results based on the relevant clinical data.Result Among 358 patients with anemia,12 cases were positive for antibiotic-induced antibodies by the drug-coated RBCs method,with the positive rate of 3.35%.Of these,284 cases were tested by cephalosporin-type antibodies and 6 were positive with the positive rate of 2.11%;74 cases were tested by non-cephalosporin-type antibodies and 6 were positive with the positive rate of 8.11%.There was significant difference between the two positive rates of antibiotic-induced antibodies(P<0.05).Twelve patients with positive antibiotic-induced antibodies were statistically compared by gender,age,surgical and non-surgical,and there's no statistically significant difference(P>0.05).No antibiotic-induced antibodies in all samples were detected using drug-addition method.Conclusion The detection rate of antibiotic-induced antibodies was different between the two methods.The positive rate of drug-coated RBCs method was significantly higher than that of drug-addition method.Blood transfusion physicians and clinicians should pay more attention to the adverse effects of antibiotic-induced antibodies.

关 键 词：药物诱导性免疫性溶血性贫血 抗生素 药物性抗体 

分 类 号：R556.6[医药卫生—血液循环系统疾病]