武汉地区献血者TPPA确证阳性人群特征分析  

Analysis on the Characteristics of TPPA Confirmed Reactive Population of Voluntary Blood Donors in Wuhan

作　　者：陈邦锐[1] 赵磊[1] 许婷婷[1] 刘涛[1] 张红[1] 乐淼[1] CHEN Bang-rui;ZHAO Lei;XU Ting-ting(Wuhan Blood Center,430030)

机构地区：[1]武汉血液中心,430030

出　　处：《临床输血与检验》2021年第3期336-339,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：武汉市卫生计生委医学科研项目(No.WG18Z06)资助。

摘　　要：目的分析武汉地区无偿献血者梅毒螺旋体明胶凝集实验(TPPA)阳性人群结构特征。方法收集武汉地区2018年1月~6月无偿献血者梅毒初筛ELISA阳性样本,进行TPPA确证,结合献血者信息进行人群结构特征分析。结果无偿献血者78997人中,男性献血者51738人,女性献血者27259人;梅毒ELISA初筛阳性331例,经TPPA确证实验有212例呈阳性,其中男性献血者119例,阳性率0.23%(119/51738),女性献血者93例,阳性率0.34%(93/27259),梅毒确证阳性率在不同性别间差异有统计学意义(χ^(2)=8.24,P<0.05);已婚139例,未婚73例,不同婚姻状况间差异有统计学意义(χ^(2)=36.13,P<0.05);按年龄段划分以18~25岁最低,阳性率为0.08%,36~45岁最高,阳性率为0.66%,不同的年龄组间差异有统计学意义(χ^(2)=149.80,P<0.05);按文化程度分析,以中专学历献血者最高,确证阳性率为0.76%,本科阳性率最低为0.10%,不同的文化程度间差异有统计学意义(χ^(2)=141.04,P<0.05);按职业划分以农民和工人最高,阳性率均为0.66%,学生阳性率最低为0.05%,在不同的职业组间差异有统计学意义(χ^(2)=177.10,P<0.05)。结论献血者招募时要重点关注低学历已婚女性献血者,属于梅毒高危人群,在血液采集前做好献血前的征询工作,降低血液风险,提高血液安全。Objective To analyze the characteristics of reactive population in treponema pallidum particle assay(TPPA)among voluntary blood donors(BDs)in Wuhan area.Methods The positive samples by ELISA from voluntary blood donors in Wuhan were collected and confirmed by TPPA from January 2018 to June 2018.Combined with the personal information,the structural characteristics of the population were analyzed.Results Among 78997 voluntary blood donors,51738 were male blood donors and 27259 female blood donors.212 cases were confirmed reactive by TPPA,including 119 males and 93 females.The positive rate of syphilis confirmed by TPPA was 0.23%(119/51738)in male blood donors and 0.34%(93/27259)in female blood donors,and there was significantly different between gender groups(χ^(2)=8.24,P<0.05).139 cases were married and 73 unmarried and there was statistical different in marital status groups(χ^(2)=36.13,P<0.05).Among age groups,the highest positive ratio was shown in 36~45 years old with 0.66%and there was statistical different in different age groups(χ^(2)=149.80,P<0.05).Considering education level,the blood donors with technical secondary school degree showed the highest positive rate 0.76%and there was statistical different in education groups(χ^(2)=141.04,P<0.05).Farmers and workers had the highest positive ratio 0.66%,and there was statistical different in occupation groups(χ^(2)=177.10,P<0.05).Conclusion We should focus on the married female blood donors with low education background,who belong to high-risk groups of syphilis.We should do a good job of consultation before blood donation,so as to reduce blood risk and improve blood safety.

关 键 词：武汉地区 献血者 梅毒螺旋体 梅毒螺旋体明胶凝集试验 

分 类 号：R446.6[医药卫生—诊断学]