多巴胺与硝普钠联用在心肌梗死后左心衰竭治疗中的作用机制探析  

Mechanism of dopamine and sodium nitroprusside in the treatment of left heart failure after myocardial infarction

作　　者：黄华杰[1] 钟凌 HUANG Hua-jie;ZHONG Ling(Suixi County People’s Hospital,Zhanjiang 524300,China)

机构地区：[1]遂溪县人民医院,524300 [2]怀集县人民医院,526400

出　　处：《中国现代药物应用》2021年第11期23-26,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨多巴胺与硝普钠联用在心肌梗死后左心衰竭治疗中的作用机制。方法98例心肌梗死后左心衰竭患者,采用随机数字表法分为对照组与观察组,各49例。对照组实施多巴胺治疗,观察组实施多巴胺+硝普钠治疗。比较两组心功能改善情况、治疗效果、症状缓解时间、住院时间、不良反应发生情况、神经功能缺损评分。结果治疗后,观察组左室射血分数(49.69±0.46)%高于对照组的(45.67±0.35)%,B型利钠肽(101.24±14.17)ng/L、N末端B型利钠肽前体(598.68±12.91)ng/L低于对照组的(111.28±14.28)、(615.28±12.58)ng/L,差异有统计学意义(P<0.05)。观察组治疗总有效率为81.63%,高于对照组的59.18%,差异有统计学意义(P<0.05)。观察组症状缓解时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为14.29%,低于对照组的32.65%,差异有统计学意义(P<0.05)。治疗后,观察组神经功能缺损评分低于对照组,差异有统计学意义(P<0.05)。结论在心肌梗死后左心衰竭治疗中,联用使用多巴胺与硝普钠能改善患者的心功能,提高治疗效果,缩短症状缓解时间及住院时间,降低不良反应发生率,降低神经功能缺损评分,值得临床推广。Objective To discuss the mechanism of dopamine and sodium nitroprusside in the treatment of left heart failure after myocardial infarction.Methods A total of 98 cases of left heart failure after myocardial infarction were randomly divided into control group and observation group according to random numerical table,with 49 cases in each group.The control group was treated with dopamine,and the observation group was treated with dopamine and sodium nitroprusside.The improvement of cardiac function,therapeutic effect,symptom remission time,hospitalization time,occurrence of adverse reactions,and neurological deficit score were compared between the two groups.Results After treatment,the left ventricular ejection fraction(49.69±0.46)%of the observation group was higher than(45.67±0.35)%of the control group,and B-type natriuretic peptide(101.24±14.17)ng/L and N-terminal pro-B-type natriuretic peptide(598.68±12.91)ng/L were lower than(111.28±14.28)and(615.28±12.58)ng/L of the control group.All the difference was statistically significant(P<0.05).The total effective rate of the observation group was 81.63%,which was higher than 59.18%of the control group,and the difference was statistically significant(P<0.05).The symptom remission time and hospitalization time of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 14.29%,which was lower than 32.65%of the control group,and the difference was statistically significant(P<0.05).After treatment,the neurological deficit score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of dopamine and sodium nitroprusside can improve the cardiac function,shorten symptom recovery time,hospitalization time,lower the incidence of adverse reactions,and reduce the neurological deficit score.It is worthy of clinical promotion.

关 键 词：心肌梗死 左心衰竭 多巴胺 硝普钠 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]