高频通气联合西地那非治疗新生儿持续性肺动脉高压的临床疗效分析  

Clinical efficacy analysis of high-frequency ventilation combined with sildenafil in the treatment of neonates with persistent pulmonary hypertension

作　　者：梁大康 陈洁静[1] LIANG Da-kang;CHEN Jie-jing(Sihui People’s Hospital,Sihui 526200,China)

机构地区：[1]四会市人民医院,526200

出　　处：《中国现代药物应用》2021年第11期115-118,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨高频通气联合西地那非治疗新生儿持续性肺动脉高压的临床疗效。方法75例新生儿持续性肺动脉高压患儿,根据随机数字法分为对照1组、对照2组、研究组,每组25例。三组均给予抗感染、内环境稳定等相关治疗。对照1组采用高频通气治疗,对照组2组采用西地那非治疗,研究组采用高频通气联合西地那非治疗。比较三组患儿治疗前后血气指标、肺动脉收缩压(SPAP)、体循环收缩压(SBP)水平以及临床疗效、死亡率。结果治疗后,研究组动脉血氧分压(PaO_(2))(81.72±11.25)mm Hg(1 mm Hg=0.133 kPa)、血氧饱和度(SpO_(2))(97.61±9.44)%均高于对照1组的(70.24±8.47)mm Hg、(89.62±8.14)%和对照2组的(70.15±8.29)mm Hg、(89.58±8.01)%,动脉血二氧化碳分压(PaCO_(2))(33.74±4.73)mm Hg低于对照1组的(45.11±5.16)mm Hg和对照2组的(45.07±5.21)mm Hg,差异均具有统计学意义(P<0.05)。治疗后,研究组患儿SPAP(28.45±3.15)mm Hg低于对照1组的(57.81±5.07)mm Hg和对照2组的(57.77±5.02)mm Hg,SBP(64.15±5.78)mm Hg高于对照1组的(53.81±5.92)mm Hg和对照2组的(53.79±5.89)mm Hg,差异均具有统计学意义(P<0.05)。研究组治疗总有效率88.0%高于对照1组的60.0%和对照2组的60.0%,差异具有统计学意义(P<0.05)。研究组死亡率4.0%低于对照1组的32.0%和对照组2组的28.0%,差异具有统计学意义(P<0.05)。结论新生儿持续性肺动脉高压的治疗中,高频通气联合西地那非治疗效果理想,值得推广应用。Objective To discuss the clinical efficacy of high-frequency ventilation combined with sildenafil in the treatment of neonates with persistent pulmonary hypertension.Methods A total of 75 neonates with persistent pulmonary hypertension were divided into control group 1,control group 2 and research group according to random numerical table,with 25 cases in each group.All three groups received anti infection,internal environment stability and other related treatment.The control group 1 was treated with high-frequency ventilation,control group 2 was treated with sildenafil,and research group was treated with high-frequency ventilation combined with sildenafil.The blood gas indexes,systolic pulmonary artery pressure(SPAP),systolic blood pressure(SBP),clinical efficacy,and death rate of the three groups were compared.Results After treatment,the partial pressure of oxygen(PaO_(2))(81.72±11.25)mm Hg(1 mm Hg=0.133 kPa)and blood oxygen saturation(SpO_(2))(97.61±9.44)%of the research group were higher than control group 1[(70.24±8.47)mm Hg,(89.62±8.14)%]and control group 2[(70.15±8.29)mm Hg,(89.58±8.01)%],and arterial partial pressure of carbon dioxide(PaCO_(2))(33.74±4.73)mm Hg was lower than(45.11±5.16)mm Hg of control group 1 and(45.07±5.21)mm Hg of control group 2.All the difference was statistically significant(P<0.05).After treatment,the SPAP(28.45±3.15)mm Hg of the research group was lower than(57.81±5.07)mm Hg of control group 1 and(57.77±5.02)mm Hg of control group 2,and SBP(64.15±5.78)mm Hg was higher than(53.81±5.92)mm Hg of control group 1 and(53.79±5.89)mm Hg of control group 2.All the difference was statistically significant(P<0.05).The total effective rate 88.0%of the research group was higher than 60.0%of control group 1 and 60.0%of control group 2,and the difference was statistically significant(P<0.05).The death rate 4.0%of the research group was lower than 32.0%of control group 1 and 28.0%of control group 2,and the difference was statistically significant(P<0.05).Conclusion Combination of

关 键 词：高频通气 西地那非 新生儿 持续性肺动脉高压 

分 类 号：R722.1[医药卫生—儿科]