ST段抬高型心肌梗死患者lncRNA-ZFAS1/Caspase-3轴的变化及其与急诊PCI预后的关系  

The changes of lncRNA-ZFAS1/Caspase-3 axis in patients with ST-segment elevation myocardial infarction and its relationship with prognosis of emergency PCI

作　　者：梁海军[1] 颜文华[1] 梁宇晨 LIANG Haijun;YAN Wenhua;LIANG Yuchen(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China;School of Life Sciences,Sichuan University,Chengdu,Sichuan 610000,China)

机构地区：[1]郑州大学第五附属医院,河南省郑州市450000 [2]四川大学生命科学学院,四川省成都市610000

出　　处：《中国动脉硬化杂志》2021年第7期611-616,共6页Chinese Journal of Arteriosclerosis

摘　　要：目的研究ST段抬高型心肌梗死(STEMI)患者lncRNA-ZFAS1/Caspase-3轴的变化及其与急诊经皮冠状动脉介入治疗(PCI)预后的关系。方法选择接受急诊PCI的STEMI患者作为STEMI组,同期体检的健康志愿者作为对照组,检测外周血lncRNA-ZFAS1的表达水平及血清Caspase-3含量,随访STEMI患者PCI术后6个月发生主要不良心血管事件(MACE)的情况,采用Kaplan-Meier曲线分析STEMI组lncRNA-ZFAS1不同表达水平患者MACE的差异,采用ROC曲线分析lncRNA-ZFAS1对STEMI患者MACE的预测价值,采用Logistic回归模型分析STEMI患者MACE的影响因素。结果STEMI患者外周血lncRNA-ZFAS1的表达水平及血清Caspase-3含量均高于对照组(P<0.05),且lncRNA-ZFAS1表达水平与血清Caspase-3含量具有正相关关系;STEMI组高lncRNA-ZFAS1表达患者的MACE累积发生率高于低lncRNA-ZFAS1表达患者;lncRNA-ZFAS1表达对STEMI患者MACE具有预测价值;cTnI峰值、多支病变、发病至PCI时间、Gensini积分、lncRNA-ZFAS1、Caspase-3是STEMI患者发生MACE的影响因素。结论STEMI患者lncRNA-ZFAS1/Caspase-3轴发生显著改变,lncRNA-ZFAS1表达水平和凋亡分子Caspase-3含量增加,且与PCI术后发生MACE有关。Aim To investigate the changes of lncRNA-ZFAS1/Caspase-3 axis in patients with ST-segment elevation myocardial infarction(STEMI)and its relationship with prognosis of emergency percutaneous coronary intervention(PCI).Methods STEMI patients who received emergency PCI were selected as STEMI group,and the healthy volunteers during the same period were selected as control group.The expression level of lncRNA-ZFAS1 in peripheral blood and the content of Caspase-3 in serum were detected.The occurrence of major adverse cardiovascular events(MACE)of STEMI patients within 6 months after PCI was followed up.Kaplan-Meier curve was used to analyze the difference of MACE in patients with different levels of lncRNA-ZFAS1 expression in STEMI group,ROC curve was used to analyze the predictive value of lncRNA-ZFAS1 for MACE in STEMI patients,Logistic regression model was used to analyze the influencing factors of MACE in STEMI patients.Results The expression level of lncRNA-ZFAS1 in peripheral blood and serum content of Caspase-3 in STEMI group were higher than those in the control group(P<0.05),and lncRNA-ZFAS1 was positively correlated with Caspase-3.The cumulative incidence of MACE in patients with high lncRNA-ZFAS1 expression was higher than that in patients with low lncRNA-ZFAS1 expression in STEMI group,lncRNA-ZFAS1 expression had predictive value for MACE in STEMI group.cTnI peak value,multi vessel disease,and time from onset to PCI,Gensini score,lncRNA-ZFAS1 and Caspase-3 were the influencing factors of MACE in STEMI patients.Conclusion The lncRNA-ZFAS1/Caspase-3 axis was significantly changed in STEMI,and lncRNA-ZFAS1 expression level and Caspase-3 content were increased,which were related to MACE after PCI.

关 键 词：ST段抬高型心肌梗死 经皮冠状动脉介入治疗 lncRNA-ZFAS1 CASPASE-3 主要不良心血管事件 

分 类 号：R5[医药卫生—内科学]