肉苁蓉化学成分和药理作用研究进展及质量标志物(Q-Marker)的预测分析  

Research progress on chemical constituents and pharmacological effects of Cistanche deserticola and predictive analysis of quality markers(Q-Marker)

作　　者：支雅婧 甄亚钦[1,2,3] 田伟 麻景梅[1,2,3] 牛丽颖 ZHI Ya-jing;ZHEN Ya-qin;TIAN Wei;MA Jing-mei;NIU Li-ying(Hebei University of Chinese Medicine,Shijiazhuang 050091,China;Hebei TCM Formula Granule Innovation Center,Shijiazhuang 050091,China;Hebei TCM Quality Evaluation&Standardization Engineering Research Center,Shijiazhuang 050091,China)

机构地区：[1]河北中医学院,河北石家庄050091 [2]河北省中药配方颗粒技术创新中心,河北石家庄050091 [3]河北省中药材品质评价与标准化工程研究中心,河北石家庄050091

出　　处：《中草药》2021年第9期2758-2767,共10页Chinese Traditional and Herbal Drugs

基　　金：河北省中医药管理局科研计划项目(2017016);河北省自然科学基金资助项目(H2019423050)。

摘　　要：肉苁蓉是一味含有多种化学成分并具有补益作用的中药,近年来研究发现其有着广泛的药理作用,主要用于神经保护、免疫调节、抗衰老、抗骨质疏松、保肝护肝等。本文通过综述肉苁蓉化学成分及其药理作用的研究现状,并在此基础上基于中药质量标志物(Q-Marker)的概念,从生源途径、传统功效、不同配伍等方面对肉苁蓉Q-Marker进行预测分析,推测肉苁蓉中的毛蕊花糖苷、异毛蕊花糖苷、松果菊苷等苯乙醇苷类,甘露糖醇等多糖,6-去氧梓醇、京尼平苷酸等环烯醚萜类,(+)-丁香树脂酚-O-β-D-葡萄糖苷等木脂素类物质及绿原酸、咖啡酸等有机酸,缬氨酸、亮氨酸、赖氨酸等氨基酸成分可作为其质量标志物,为其质量评价提供一定的参考。Roucongrong(Cistanche deserticola)is a Chinese medicine containing a variety of chemical components and has a tonic effect.In recent years,it has been found to have a wide range of pharmacological effects,mainly used for neuroprotection,immune regulation,anti-aging,anti-osteoporosis,liver protection,etc.In this paper,the research status of chemical composition and pharmacological action of C.deserticola was summarized,and on this basis,based on the concept of traditional Chinese medicine quality marker(Q-Marker),Q-Marker was predicted and analyzed from the aspects of source pathway,traditional efficacy,different compatibilities,and measurable chemical composition.It was pridicted that phenylethanoid glycosides such as acteoside、isoacteoside and echinacoside,polysaccharides such as mannitol,iridoids such as 6-deoxycatalpol and geniposidic acid,lignins such as(+)-pinoresinol-O-β-D-glucopyranoside,organic acids such as chlorogenic acids、caffeic acid and amino acids such as valine、leucine、lysine can be used as Q-Marker in C.deserticola,which can provide certain reference for quality evaluation of C.deserticola.

关 键 词：肉苁蓉 生源途径 传统功效 质量标志物 毛蕊花糖苷 异毛蕊花糖苷 松果菊苷 6-去氧梓醇 京尼平苷酸 

分 类 号：R286[医药卫生—中药学]