青龙衣化学成分和药理作用研究进展及质量标志物的预测分析  

Research progress on chemical composition and pharmacological effects and predictive analysis on quality markers of Qinglongyi

作　　者：陈乐乐 李珩玉 周祥禄 陈曙光 展照双[1] 王加锋[1] CHEN Le-le;LI Heng-yu;ZHOU Xiang-lu;CHEN Shu-guang;ZHAN Zhao-shuang;WANG Jia-feng(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《中草药》2021年第9期2785-2800,共16页Chinese Traditional and Herbal Drugs

基　　金：山东中医药大学科研创新团队项目(2018-10);山东省中医药科技发展计划项目(2019-0041);山东省中医药科技发展计划项目(2019-0042);齐鲁医派中医学术流派传承项目(齐鲁道地药材炮制存性特色技术)。

摘　　要：查阅近年来国内外相关文献,在对青龙衣化学成分及现代药理作用研究的基础上,根据中药质量标志物(Q-Marker)概念,从化学成分与亲缘关系、传统药效与药性及成分可测性、采收时期和干燥方法等方面,对青龙衣Q-Marker成分进行预测分析,发现胡桃醌、胡桃酮、绿原酸、核桃素A、核桃素B、马尾树素可作为青龙衣的Q-Marker,后续可选择以上成分作为指标,为青龙衣质量评价体系的建立提供参考。Qinglongyi is plant of genus Juglans of Juglandaceae,which is often used to treat skin itching and pain.In recent years,with the in-depth study of Qinglongyi,its various chemical constituents,wide range of pharmacological effects and clinical application development have attracted much attention.In this paper,by consulting the relevant literatures at home and abroad in recent years,on the basis of summarizing the chemical composition and modern pharmacological action of Qinglongyi,and according to the concept of traditional Chinese medicine quality marker(Q-Marker),the composition of Qinglongyi quality marker was predicted and analyzed from the aspects of chemical composition and genetic relationship,traditional efficacy and property,measurability of components,harvest time and drying method.It was suggested that juglone,walnut ketone,chlorogenic acid,Qinglongyi inorganic salt,juglanin A,juglanin B,horseradin and total flavonoids can be used as Q-Marker in Qinglongyi.In the follow-up,the above components can be selected as indicators to provide a scientific basis for the quality evaluation of Qinglongyi.

关 键 词：青龙衣 胡桃醌 胡桃酮 绿原酸 核桃素A 核桃素B 马尾树素 Q-Marker 预测分析 

分 类 号：R286[医药卫生—中药学]