竹节参的化学成分、药理作用及质量标志物(Q-Marker)预测分析  

Research progress on chemical constituents and pharmacological effects of Panax japonicus and predictive analysis on quality markers

作　　者：周静 付先芸 蔡三金[1] 袁丁[1] 梅志刚 冯知涛 ZHOU Jing;FU Xian-yun;CAI San-jin;YUAN Ding;MEI Zhi-gang;FENG Zhi-tao(Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration Chinese Medicine,College of Medicine,China Three Gorges University,Yichang 443002,China;Hunan Key Laboratory of Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]三峡大学医学院,国家中医药管理局中药药理科研三级实验室,湖北宜昌443002 [2]湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室,湖南长沙410208

出　　处：《中草药》2021年第9期2819-2830,共12页Chinese Traditional and Herbal Drugs

基　　金：湖北省医学青年拔尖第一层次人才项目(EWT2019-48)。

摘　　要：竹节参为五加科人参属植物,在我国主要分布于湖北、云南、贵州及四川等地,以湖北恩施分布最为丰富。因其既具有人参的补益作用又具三七的活血作用,常被作为民族药用于治疗跌打损伤、关节炎以及虚劳等气虚血瘀证。竹节参主要化学成分为皂苷类、糖类、氨基酸类、挥发油类、核苷类及无机盐类。研究显示,竹节参具有抗疲劳、保肝、镇静、保护心脑血管、免疫调节、抗肿瘤、抗衰老及抗炎等药理作用。对国内外关于竹节参的化学成分、药理作用的研究进展进行综述,并对其质量标志物(quality marker,Q-Marker)进行预测分析,越南参皂苷R1、越南参皂苷R2、竹节参皂苷Ⅳa和竹节参皂苷Ⅴ等化合物可作为竹节参的主要Q-Marker,为竹节参质量评价体系的建立提供依据和相关新药研发提供参考。Zhujieshen(Panax japonicus)belongs to the Panax genus of Acanthaceae,which is mainly distributed in Hubei,Yunnan,Guizhou,Sichuan and other places in China,with Enshi in Hubei being the most abundant.Because of its tonic effect as Ginseng Radix et Rhizoma and the activating effect as Notoginseng Radix et Rhizoma,it is often used as an ethnic medicine to treat the syndrome of qi deficiency and blood stasis,such as traumatic injury,arthritis,and deficiency of fatigue.The main chemical constituents of P.japonicus are saponins,sugars,amino acids,essential oils,nucleosides,and inorganic salts.Studies showed that P.japonicus had antifatigue,liver protection,sedation,cardio-cerebrovascular protection,immune regulation,anti-tumor,anti-aging,and anti-inflammatory pharmacological effects.This paper reviewed the research progress on chemical constituents and pharmacological effects of P.japonicus at home and abroad,and analyzed its quality markers(Q-marker).Vina-ginsenoside R1,vina-ginsenoside R2,chikusetsusaponinⅣa and chikusetsusaponinⅤcan be used as the main Q-markers of P.japonicus,which provide a basis for the establishment of quality evaluation system of P.japonicus and a reference for the research and development of related new drugs.

关 键 词：竹节参 质量标志物 越南参皂苷R1 越南参皂苷R2 竹节参皂苷Ⅳa 竹节参皂苷Ⅴ 竹节参多糖 竹节参总皂苷 心脑血管系统调节 免疫调节 抗炎 

分 类 号：R282.71[医药卫生—中药学]