老年人颈-股动脉脉搏波传导速度与左心室舒张功能不全的相关性分析  

Correlation analysis of carotid-femoral pulse wave velocity and left ventricular diastolic dysfunction in the elderly

作　　者：穆林[1] 吴永全 Mu Lin;Wu Yongquan(Class A Ward,Beijing Moslem People’s Hospital,Beijing 100054,China;Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]北京市回民医院A级一病房,100054 [2]首都医科大学附属北京安贞医院心内科,100029

出　　处：《中国心血管杂志》2021年第3期224-228,共5页Chinese Journal of Cardiovascular Medicine

摘　　要：目的探讨老年人颈-股动脉脉搏波传导速度(cfPWV)与左心室舒张功能不全的相关性。方法纳入于2019年5月至2019年10月进行健康体检的牛街西里社区年龄≥60岁的老年人384例。对入选体检者均行cfPWV和左心室舒张功能的超声心动图测定。根据超声心动图检查结果,将入选者分为舒张功能正常组(127例)和舒张功能不全组(257例),比较两组临床资料、cfPWV的差异,采用Spearman相关分析评价cfPWV与主要临床变量间的相关性,二元logistic回归模型评估多个临床因素及cfPWV与左心室舒张功能之间的关系,ROC曲线计算cfPWV预测左心室舒张功能不全的截止点。结果舒张功能不全组的年龄、高血压和糖尿病患病率、空腹血糖、糖化血红蛋白、体质指数、收缩压、左心房内径、室间隔厚度、左心室后壁厚度、左心室质量指数均显著高于舒张功能正常组(均为P<0.05)。舒张功能不全组的cfPWV较舒张功能正常组显著升高[(11.9±3.5)m/s比(7.2±0.8)m/s,t=-20.436,P=0.000]。Spearman相关分析显示,cfPWV与E/E′呈显著正相关(R=0.851,P=0.000)。Logistic回归分析显示,cfPWV与左心室舒张功能不全显著相关(χ^(2)=46.999,P=0.000)。ROC曲线分析显示,以8.65 m/s为截止点,cfPWV诊断左心室舒张功能不全的敏感度为83.7%,特异度为87.2%。结论老年人cfPWV与左心室舒张功能不全显著相关。Objective To explore the correlation between carotid-femoral pulse wave velocity(cfPWV)and left ventricular diastolic dysfunction in the elderly.Methods A total of 384 subjects over 60 years old in Niujie community accepted medical examination were enrolled between May 2019 and October 2019.These participants had been measured cfPWV and left ventricular diastolic function by echocardiography for the selected physical examinations.According to the results of echocardiography,they were divided into two groups according to their left ventricular diastolic:subjects with normal diastolic function group(n=127)and with diastolic dysfunction group(n=257).The clinical data and cfPWV in both groups were compared.Spearman correlation analysis was used to evaluate the correlation between cfPWV and main clinical variables.A binary logistic regression model was used to evaluate the relationship between multiple clinical variables including cfPWV and left ventricular diastolic function.The cut-off point of cfPWV for predicting left ventricular diastolic dysfunction was derived from the receiver operator characteristic(ROC)curve.Results The age,prevalence of hypertension and diabetes,fasting glucose,glycated haemoglobin,body mass index,systolic blood pressure,left atrial diameter,interventricular septal thickness,left ventricular posterior wall thickness,and left ventricular mass index were significantly higher in diastolic dysfunction group than in normal diastolic function group(all P<0.05).Compared with normal diastolic function group,the cfPWV of diastolic dysfunction group was significantly higher[(11.9±3.5)m/s vs.(7.2±0.8)m/s,t=-20.436,P=0.000].Spearman correlation analysis showed that cfPWV was positively correlated with E/E′(R=0.851,P=0.000).Binary logistic regression analysis showed that cfPWV was significantly related to left ventricular diastolic dysfunction(χ^(2)=46.999,P=0.000).The ROC curve demonstrated that a cfPWV of 8.65 m/s was useful to discriminate left ventricular diastolic dysfunction(sensitivity 83.7%

关 键 词：颈-股动脉脉搏波传导速度 左心室舒张功能不全 老年人 

分 类 号：R54[医药卫生—心血管疾病]